Genome-Wide Dna Methylation Profiling Using Infinium® Assay
M Bibikova, J Le, B Barnes, S Saedinia-Melnyk… - …, 2009 - Taylor & Francis
Aims: Bisulfite sequence analysis of individual CpG sites within genomic DNA is a powerful
approach for methylation analysis in the genome. The major limitation of bisulfite-based …
approach for methylation analysis in the genome. The major limitation of bisulfite-based …
[HTML][HTML] High density DNA methylation array with single CpG site resolution
M Bibikova, B Barnes, C Tsan, V Ho, B Klotzle, JM Le… - Genomics, 2011 - Elsevier
We have developed a new generation of genome-wide DNA methylation BeadChip which
allows high-throughput methylation profiling of the human genome. The new high density …
allows high-throughput methylation profiling of the human genome. The new high density …
Genome‐wide DNA methylation profiling
M Bibikova, JB Fan - Wiley Interdisciplinary Reviews: Systems …, 2010 - Wiley Online Library
DNA methylation plays a critical role in the regulation of gene expression. The ability to
access the methylation status for a large number of genes or the entire genome should …
access the methylation status for a large number of genes or the entire genome should …
Mining cancer methylomes: prospects and challenges
There are over 28 million CpG sites in the human genome. Assessing the methylation status
of each of these sites will be required to understand fully the role of DNA methylation in …
of each of these sites will be required to understand fully the role of DNA methylation in …
[HTML][HTML] DNA methylome profiling of human tissues identifies global and tissue-specific methylation patterns
Background DNA epigenetic modifications, such as methylation, are important regulators of
tissue differentiation, contributing to processes of both development and cancer. Profiling the …
tissue differentiation, contributing to processes of both development and cancer. Profiling the …
Dynamic DNA methylation across diverse human cell lines and tissues
As studies of DNA methylation increase in scope, it has become evident that methylation has
a complex relationship with gene expression, plays an important role in defining cell types …
a complex relationship with gene expression, plays an important role in defining cell types …
High definition profiling of mammalian DNA methylation by array capture and single molecule bisulfite sequencing
DNA methylation stabilizes developmentally programmed gene expression states. Aberrant
methylation is associated with disease progression and is a common feature of cancer …
methylation is associated with disease progression and is a common feature of cancer …
Whole genome DNA methylation analysis based on high throughput sequencing technology
N Li, M Ye, Y Li, Z Yan, LM Butcher, J Sun, X Han… - Methods, 2010 - Elsevier
There are numerous approaches to decipher a whole genome DNA methylation profile
(“methylome”), each varying in cost, throughput and resolution. The gold standard of these …
(“methylome”), each varying in cost, throughput and resolution. The gold standard of these …
Tagmentation-based whole-genome bisulfite sequencing
Epigenetic modifications such as carbon 5 methylation of the cytosine base in a CpG
dinucleotide context are involved in the onset and progression of human diseases. A …
dinucleotide context are involved in the onset and progression of human diseases. A …
BiQ Analyzer HT: locus-specific analysis of DNA methylation by high-throughput bisulfite sequencing
Bisulfite sequencing is a widely used method for measuring DNA methylation in eukaryotic
genomes. The assay provides single-base pair resolution and, given sufficient sequencing …
genomes. The assay provides single-base pair resolution and, given sufficient sequencing …