Evidence for biological age acceleration and telomere shortening in COVID-19 survivors

A Mongelli, V Barbi, M Gottardi Zamperla… - International journal of …, 2021 - mdpi.com
The SARS-CoV-2 infection determines the COVID-19 syndrome characterized, in the worst
cases, by severe respiratory distress, pulmonary and cardiac fibrosis, inflammatory cytokine …

Accelerated biological aging in COVID-19 patients

X Cao, W Li, T Wang, D Ran, V Davalos… - Nature …, 2022 - nature.com
Chronological age is a risk factor for SARS-CoV-2 infection and severe COVID-19. Previous
findings indicate that epigenetic age could be altered in viral infection. However, the …

[HTML][HTML] Shorter telomere lengths in patients with severe COVID-19 disease

R Sanchez-Vazquez, A Guío-Carrión… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
The incidence of severe manifestations of COVID-19 increases with age with older patients
showing the highest mortality, suggesting that molecular pathways underlying aging …

Understanding the role of telomere attrition and epigenetic signatures in COVID-19 severity

A Mahmoodpoor, S Sanaie, F Roudbari, T Sabzevari… - Gene, 2022 - Elsevier
Within the past several decades, the emergence and spread of infectious diseases with
pandemic potential have endangered human lives. Coronavirus disease 2019 (COVID-19) …

[HTML][HTML] Causal association of epigenetic aging and COVID-19 severity and susceptibility: a bidirectional Mendelian randomization study

W Xu, F Zhang, Y Shi, Y Chen, B Shi, G Yu - Frontiers in Medicine, 2022 - frontiersin.org
Observational data from China, the United States, France, and Italy suggest that aging is an
adverse COVID-19 outcome risk factor, with older patients having a higher severity and …

[HTML][HTML] Short telomeres increase the risk of severe COVID-19

A Froidure, M Mahieu, D Hoton, PF Laterre… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
Telomeres are non-coding DNA sequences that protect chromosome ends and shorten with
age. Short telomere length (TL) is associated with chronic diseases and …

DNA damage response at telomeres boosts the transcription of SARS‐CoV‐2 receptor ACE2 during aging

S Sepe, F Rossiello, V Cancila, F Iannelli, V Matti… - EMBO …, 2022 - embopress.org
The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) causes the
coronavirus disease 2019 (COVID‐19), known to be more common in the elderly, who also …

Association between COVID‐19 and telomere length: a bidirectional Mendelian randomization study

D Huang, S Lin, J He, Q Wang… - Journal of medical …, 2022 - Wiley Online Library
Several traditional observational studies suggested an association between COVID‐19 and
leukocyte telomere length (LTL), a biomarker for biological age. However, whether there …

[HTML][HTML] Why does COVID-19 disproportionately affect older people?

AL Mueller, MS McNamara, DA Sinclair - Aging (albany NY), 2020 - ncbi.nlm.nih.gov
The severity and outcome of coronavirus disease 2019 (COVID-19) largely depends on a
patient's age. Adults over 65 years of age represent 80% of hospitalizations and have a 23 …

[HTML][HTML] Role of senescence in the chronic health consequences of COVID-19

EOW Gerdes, G Vanichkachorn, BP Verdoorn… - Translational …, 2022 - Elsevier
While the full impact of COVID-19 is not yet clear, early studies have indicated that upwards
of 10% of patients experience COVID-19 symptoms longer than 3 weeks, known as Long …