Genomic analysis of longevity offers the potential to illuminate the biology of human aging.
Here, using genome-wide association meta-analysis of 606,059 parents' survival, we …

Human longevity is heritable, but genome-wide association (GWA) studies have had limited
success. Here, we perform two meta-analyses of GWA studies of a rigorous longevity …

There is growing interest in studying the genetic contributions to longevity, but limited
relevant genes have been identified. In this study, we performed a genetic association study …

Clear evidence exists for heritability of human longevity, and much interest is focused on
identifying genes associated with longer lives. To identify such longevity alleles, we …

Variation in human lifespan is 20 to 30% heritable in twins but few genetic variants have
been identified. We undertook a Genome Wide Association Study (GWAS) using age at …

Only two genome-wide significant loci associated with longevity have been identified so far,
probably because of insufficient sample sizes of centenarians, whose genomes may harbor …

Research into the genetic component of human longevity can provide important insights in
mechanisms that may protect against age-related diseases and multi-morbidity. Thus far …

The genetic contribution to the variation in human lifespan is∼ 25%. Despite the large
number of identified disease-susceptibility loci, it is not known which loci influence …

Ageing phenotypes, such as years lived in good health (healthspan), total years lived
(lifespan), and survival until an exceptional old age (longevity), are of interest to us all but …

Understanding the genetic basis of human longevity remains a challenge but could lead to
life-extending interventions and better treatments for age-related diseases. Toward this end …