A comprehensive characterization of epigenomic organization in the embryonic mouse
forebrain will enhance our understanding of neurodevelopment and provide insight into …

Dynamic changes in chromatin accessibility coincide with important aspects of neuronal
differentiation, such as fate specification and arealization and confer cell type-specific …

During mammalian development, differences in chromatin state coincide with cellular
differentiation and reflect changes in the gene regulatory landscape. In the developing brain …

Abstract Analysis of chromatin accessibility can reveal transcriptional regulatory sequences,
but heterogeneity of primary tissues poses a significant challenge in mapping the precise …

INTRODUCTION The cerebral cortex is responsible for higher-order functions in the nervous
system and has undergone substantial expansion in size in primates. The development of …

Understanding the cellular and genetic mechanisms driving human-specific features of
cortical development remains a challenge. We generated a cell-type resolved atlas of …

The human brain is capable of highly complex functions that develops through a tightly
organized cascade of patterning events, expressed transcription factors and changes in …

Epigenetic regulation plays an important role in controlling gene expression during complex
processes, such as development of the human brain. Mutations in genes encoding …

How multiple epigenetic layers and transcription factors (TFs) interact to facilitate brain
development is largely unknown. Here, to systematically map the regulatory landscape of …

The development of the human neocortex is a highly dynamic process and involves complex
cellular trajectories controlled by cell-type-specific gene regulation. Here, we collected …