The search for the genetic factors contributing to Alzheimer disease (AD) has evolved
tremendously throughout the years. It started from the discovery of fully penetrant mutations …

The genetic underpinnings of Alzheimer's disease (AD) remain largely elusive despite early
successes in identifying three genes that cause early-onset familial AD (those that encode …

Linkage studies, candidate gene and whole-genome association studies have resulted in a
tremendous amount of putative risk genes for Alzheimer's disease (AD). Yet, besides the …

Alzheimer's disease (AD) is the most frequent cause of dementia in the elderly and
represents an important and increasing clinical challenge in terms of diagnosis and …

Alzheimer's disease (AD) is a complex disorder of the central nervous system (CNS).
Molecular genetic research has provided a wealth of information regarding the genetic …

Alzheimer disease (AD), a progressive and neurodegenerative disease, is the most common
form of dementia with high incidence in elderly people. Neuropathologically the disease is …

Alzheimer's disease (AD) is a clinically heterogeneous neurodegenerative disease with a
strong genetic component. Several genes have been associated with AD risk for nearly 20 …

Genetic factors play a major role in determining a person's risk to develop Alzheimer's
disease (AD). Rare mutations transmitted in a Mendelian fashion within affected families, for …

Three decades of genetic research in Alzheimer disease (AD) have substantially broadened
our understanding of the pathogenetic mechanisms leading to neurodegeneration and …

Alzheimer's disease (AD) is considered to have a large genetic component. Our knowledge
of this component has progressed over the last 10 years, thanks notably to the advent of …