A systematic study of normalization methods for Infinium 450K methylation data using whole-genome bisulfite sequencing data
DNA methylation plays an important role in disease etiology. The Illumina Infinium
HumanMethylation450 (450K) BeadChip is a widely used platform in large-scale …
HumanMethylation450 (450K) BeadChip is a widely used platform in large-scale …
Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium HumanMethylation450 microarray
Y Chen, M Lemire, S Choufani, DT Butcher… - Epigenetics, 2013 - Taylor & Francis
DNA methylation, an important type of epigenetic modification in humans, participates in
crucial cellular processes, such as embryonic development, X-inactivation, genomic …
crucial cellular processes, such as embryonic development, X-inactivation, genomic …
Mining cancer methylomes: prospects and challenges
There are over 28 million CpG sites in the human genome. Assessing the methylation status
of each of these sites will be required to understand fully the role of DNA methylation in …
of each of these sites will be required to understand fully the role of DNA methylation in …
[HTML][HTML] Genome-wide methylation analysis of human colon cancer reveals similar hypo-and hypermethylation at conserved tissue-specific CpG island shores
Alterations in DNA methylation (DNAm) in cancer have been known for 25 years, including
hypomethylation of oncogenes and hypermethylation of tumor suppressor genes 1 …
hypomethylation of oncogenes and hypermethylation of tumor suppressor genes 1 …
Comprehensive DNA methylation profiling in a human cancer genome identifies novel epigenetic targets
JM Ordway, JA Bedell, RW Citek, A Nunberg… - …, 2006 - academic.oup.com
Using a unique microarray platform for cytosine methylation profiling, the DNA methylation
landscape of the human genome was monitored at more than 21 000 sites, including 79% of …
landscape of the human genome was monitored at more than 21 000 sites, including 79% of …
Large-scale structure of genomic methylation patterns
RA Rollins, F Haghighi, JR Edwards, R Das… - Genome …, 2006 - genome.cshlp.org
The mammalian genome depends on patterns of methylated cytosines for normal function,
but the relationship between genomic methylation patterns and the underlying sequence is …
but the relationship between genomic methylation patterns and the underlying sequence is …
Introduction to epigenomics and epigenome-wide analysis
MJ Fazzari, JM Greally - Statistical Methods in Molecular Biology, 2010 - Springer
Epigenetics is the study of heritable change other than those encoded in DNA sequence.
Cytosine methylation of DNA at CpG dinucleotides is the most well-studied epigenetic …
Cytosine methylation of DNA at CpG dinucleotides is the most well-studied epigenetic …
Single-cell genome-wide bisulfite sequencing uncovers extensive heterogeneity in the mouse liver methylome
Abstract Background Transmission fidelity of CpG DNA methylation patterns is not foolproof,
with error rates from less than 1 to well over 10% per CpG site, dependent on preservation of …
with error rates from less than 1 to well over 10% per CpG site, dependent on preservation of …
Cytosine methylation profiling of cancer cell lines
DNA-methylation changes in human cancer are complex and vary between the different
types of cancer. Capturing this epigenetic variability in an atlas of DNA-methylation changes …
types of cancer. Capturing this epigenetic variability in an atlas of DNA-methylation changes …
Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood
Background Dynamic changes to the epigenome play a critical role in establishing and
maintaining cellular phenotype during differentiation, but little is known about the normal …
maintaining cellular phenotype during differentiation, but little is known about the normal …