SeSAMe: reducing artifactual detection of DNA methylation by Infinium BeadChips in genomic deletions
We report a new class of artifacts in DNA methylation measurements from Illumina
HumanMethylation450 and MethylationEPIC arrays. These artifacts reflect failed …
HumanMethylation450 and MethylationEPIC arrays. These artifacts reflect failed …
Using long-read sequencing to detect imprinted DNA methylation
Systematic variation in the methylation of cytosines at CpG sites plays a critical role in early
development of humans and other mammals. Of particular interest are regions of differential …
development of humans and other mammals. Of particular interest are regions of differential …
DNA methylation QTL mapping across diverse human tissues provides molecular links between genetic variation and complex traits
M Oliva, K Demanelis, Y Lu, M Chernoff, F Jasmine… - Nature …, 2023 - nature.com
Studies of DNA methylation (DNAm) in solid human tissues are relatively scarce; tissue-
specific characterization of DNAm is needed to understand its role in gene regulation and its …
specific characterization of DNAm is needed to understand its role in gene regulation and its …
[HTML][HTML] DNA methylation atlas of the mouse brain at single-cell resolution
Mammalian brain cells show remarkable diversity in gene expression, anatomy and
function, yet the regulatory DNA landscape underlying this extensive heterogeneity is poorly …
function, yet the regulatory DNA landscape underlying this extensive heterogeneity is poorly …
Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications
Abstract Analysis of DNA methylation patterns relies increasingly on sequencing-based
profiling methods. The four most frequently used sequencing-based technologies are the …
profiling methods. The four most frequently used sequencing-based technologies are the …
Chromatin and sequence features that define the fine and gross structure of genomic methylation patterns
JR Edwards, AH O'Donnell, RA Rollins… - Genome …, 2010 - genome.cshlp.org
Abnormalities of genomic methylation patterns are lethal or cause disease, but the cues that
normally designate CpG dinucleotides for methylation are poorly understood. We have …
normally designate CpG dinucleotides for methylation are poorly understood. We have …
Evaluation of the Infinium Methylation 450K technology
S Dedeurwaerder, M Defrance, E Calonne, H Denis… - …, 2011 - Taylor & Francis
Aims: Studies of DNA methylomes hold enormous promise for biomedicine but are
hampered by the technological challenges of analyzing many samples cost-effectively …
hampered by the technological challenges of analyzing many samples cost-effectively …
Identification of methylation haplotype blocks aids in deconvolution of heterogeneous tissue samples and tumor tissue-of-origin mapping from plasma DNA
Adjacent CpG sites in mammalian genomes can be co-methylated owing to the processivity
of methyltransferases or demethylases, yet discordant methylation patterns have also been …
of methyltransferases or demethylases, yet discordant methylation patterns have also been …
Global methylation in exposure biology and translational medical science
Background: Many groups are actively investigating how the epigenetic state relates to
environmental exposures and development of disease, including cancer. There are myriad …
environmental exposures and development of disease, including cancer. There are myriad …
[HTML][HTML] Reducing the risk of false discovery enabling identification of biologically significant genome-wide methylation status using the HumanMethylation450 array
Abstract Background The Illumina HumanMethylation450 BeadChip (HM450K) measures
the DNA methylation of 485,512 CpGs in the human genome. The technology relies on …
the DNA methylation of 485,512 CpGs in the human genome. The technology relies on …