[HTML][HTML] Shorter telomere lengths in patients with severe COVID-19 disease

R Sanchez-Vazquez, A Guío-Carrión… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
The incidence of severe manifestations of COVID-19 increases with age with older patients
showing the highest mortality, suggesting that molecular pathways underlying aging …

[HTML][HTML] Short telomeres increase the risk of severe COVID-19

A Froidure, M Mahieu, D Hoton, PF Laterre… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
Telomeres are non-coding DNA sequences that protect chromosome ends and shorten with
age. Short telomere length (TL) is associated with chronic diseases and …

[HTML][HTML] Telomeres and COVID‐19

A Aviv - The FASEB Journal, 2020 - ncbi.nlm.nih.gov
The medical, public health, and scientific communities are grappling with monumental
imperatives to contain COVID‐19, develop effective vaccines, identify efficacious treatments …

Evidence for biological age acceleration and telomere shortening in COVID-19 survivors

A Mongelli, V Barbi, M Gottardi Zamperla… - International journal of …, 2021 - mdpi.com
The SARS-CoV-2 infection determines the COVID-19 syndrome characterized, in the worst
cases, by severe respiratory distress, pulmonary and cardiac fibrosis, inflammatory cytokine …

Shorter leukocyte telomere length is associated with adverse COVID-19 outcomes: a cohort study in UK Biobank

Q Wang, V Codd, Z Raisi-Estabragh, C Musicha… - …, 2021 - thelancet.com
Background Older age is the most powerful risk factor for adverse coronavirus disease-19
(COVID-19) outcomes. It is uncertain whether leucocyte telomere length (LTL), previously …

Association between COVID‐19 and telomere length: a bidirectional Mendelian randomization study

D Huang, S Lin, J He, Q Wang… - Journal of medical …, 2022 - Wiley Online Library
Several traditional observational studies suggested an association between COVID‐19 and
leukocyte telomere length (LTL), a biomarker for biological age. However, whether there …

DNA damage response at telomeres boosts the transcription of SARS‐CoV‐2 receptor ACE2 during aging

S Sepe, F Rossiello, V Cancila, F Iannelli, V Matti… - EMBO …, 2022 - embopress.org
The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) causes the
coronavirus disease 2019 (COVID‐19), known to be more common in the elderly, who also …

Shortened telomere length in patients with depression: a meta-analytic study

PY Lin, YC Huang, CF Hung - Journal of Psychiatric Research, 2016 - Elsevier
Background Accelerated telomere shortening is associated with stress-related cell damage
and aging. Patients with depression have been shown to have shortened life expectancy …

Accelerated biological aging in COVID-19 patients

X Cao, W Li, T Wang, D Ran, V Davalos… - Nature …, 2022 - nature.com
Chronological age is a risk factor for SARS-CoV-2 infection and severe COVID-19. Previous
findings indicate that epigenetic age could be altered in viral infection. However, the …

Telomeres and age-related diseases

HJ Gruber, MD Semeraro, W Renner, M Herrmann - Biomedicines, 2021 - mdpi.com
Telomeres are at the non-coding ends of linear chromosomes. Through a complex 3-
dimensional structure, they protect the coding DNA and ensure appropriate separation of …