Age-related decline of de novo T cell responsiveness as a cause of COVID-19 severity
To the Editor, So far, little attention has been paid to the link between immunosenescence
and the dramatic mortality rate of coronavirus disease 2019 (COVID-19) in older age groups …
and the dramatic mortality rate of coronavirus disease 2019 (COVID-19) in older age groups …
[HTML][HTML] The pre-exposure SARS-CoV-2-specific T cell repertoire determines the quality of the immune response to vaccination
C Saggau, GR Martini, E Rosati, S Meise, B Messner… - Immunity, 2022 - cell.com
SARS-CoV-2 infection and vaccination generates enormous host-response heterogeneity
and an age-dependent loss of immune-response quality. How the pre-exposure T cell …
and an age-dependent loss of immune-response quality. How the pre-exposure T cell …
Impaired Cytotoxic CD8+ T Cell Response in Elderly COVID-19 Patients
J Westmeier, K Paniskaki, Z Karaköse, T Werner… - MBio, 2020 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection induces a T cell
response that most likely contributes to virus control in COVID-19 patients but may also …
response that most likely contributes to virus control in COVID-19 patients but may also …
Ageing Curtails the Diversity and Functionality of Nascent CD8+ T Cell Responses against SARS-CoV-2
D Proietto, B Dallan, E Gallerani, V Albanese… - Vaccines, 2023 - mdpi.com
Age-related changes in the immune system are thought to underlie the vulnerability of
elderly individuals to emerging viral diseases, such as coronavirus disease 2019 (COVID …
elderly individuals to emerging viral diseases, such as coronavirus disease 2019 (COVID …
SARS-CoV-2–specific CD8+ T cell responses in convalescent COVID-19 individuals
Characterization of the T cell response in individuals who recover from severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is critical to understanding its …
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is critical to understanding its …
Association of cellular immunity with severity of COVID-19 from the perspective of antigen-specific memory T cell responses and cross-reactivity
S Fujii, S Yamasaki, T Iyoda, K Shimizu - Inflammation and Regeneration, 2022 - Springer
Coronaviruses regularly cause outbreaks of zoonotic diseases characterized by severe
pneumonia. The new coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS …
pneumonia. The new coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS …
Reappearance of effector T cells is associated with recovery from COVID-19
Background Elucidating the role of T cell responses in COVID-19 is of utmost importance to
understand the clearance of SARS-CoV-2 infection. Methods 30 hospitalized COVID-19 …
understand the clearance of SARS-CoV-2 infection. Methods 30 hospitalized COVID-19 …
T cells: warriors of SARS-CoV-2 infection
P de Candia, F Prattichizzo, S Garavelli… - Trends in …, 2021 - cell.com
Severe infection with severe acute respiratory syndrome coronavirus (SARS-CoV)-2 is
characterized by massive cytokine release and T cell loss. The exaggerated host immune …
characterized by massive cytokine release and T cell loss. The exaggerated host immune …
COVID-19 and cellular senescence
CA Schmitt, T Tchkonia, LJ Niedernhofer… - Nature Reviews …, 2023 - nature.com
The clinical severity of coronavirus disease 2019 (COVID-19) is largely determined by host
factors. Recent advances point to cellular senescence, an ageing-related switch in cellular …
factors. Recent advances point to cellular senescence, an ageing-related switch in cellular …
[HTML][HTML] Antigen-specific adaptive immunity to SARS-CoV-2 in acute COVID-19 and associations with age and disease severity
Limited knowledge is available on the relationship between antigen-specific immune
responses and COVID-19 disease severity. We completed a combined examination of all …
responses and COVID-19 disease severity. We completed a combined examination of all …