The behavioral phenotype of early life adversity: A 3-level meta-analysis of rodent studies

V Bonapersona, J Kentrop, CJ Van Lissa… - Neuroscience & …, 2019 - Elsevier
Altered cognitive performance is considered an intermediate phenotype mediating early life
adversity (ELA) effects on later-life development of mental disorders, eg depression …

[HTML][HTML] Early life adversity and neuropsychiatric disease: differential outcomes and translational relevance of rodent models

RC Waters, E Gould - Frontiers in systems neuroscience, 2022 - frontiersin.org
It is now well-established that early life adversity (ELA) predisposes individuals to develop
several neuropsychiatric conditions, including anxiety disorders, and major depressive …

Enduring effects of early-life adversity on reward processes: A systematic review and meta-analysis of animal studies

M Duque-Quintero, CR Hooijmans, A Hurowitz… - Neuroscience & …, 2022 - Elsevier
Two-thirds of individuals experience adversity during childhood such as neglect, abuse or
highly-stressful events. Early-life adversity (ELA) increases the life-long risk of developing …

[HTML][HTML] Early-life stress biases responding to negative feedback and increases amygdala volume and vulnerability to later-life stress

EG Dutcher, L Lopez-Cruz, EAC Pama… - Translational …, 2023 - nature.com
Early-life stress (ELS) or adversity, particularly in the form of childhood neglect and abuse, is
associated with poor mental and physical health outcomes in adulthood. However, whether …

Type of early life adversity confers differential, sex-dependent effects on early maturational milestones in mice

C Demaestri, T Pan, M Critz, D Ofray, M Gallo… - Hormones and …, 2020 - Elsevier
Early life adversity (ELA) increases risk for negative health outcomes, with sex disparities in
prevalence and form of ELA experienced and risk for neuropsychiatric pathology. ELA …

Evidence that neuropsychological deficits following early life adversity may underlie vulnerability to depression

SA Stuart, JK Hinchcliffe, ESJ Robinson - Neuropsychopharmacology, 2019 - nature.com
Early life adversity (ELA) is a risk factor for major depressive disorder (MDD), however the
underlying mechanisms are not well understood. Clinical studies suggest that negative …

Neurostructural traces of early life adversities: A meta-analysis exploring age-and adversity-specific effects

TM Pollok, A Kaiser, EJ Kraaijenvanger… - Neuroscience & …, 2022 - Elsevier
Early life adversities (ELAs) are associated with an increased risk of psychopathology, with
studies suggesting a relation to structural brain alterations. Given the recently growing …

Impact of early life adversities on human brain functioning: A coordinate-based meta-analysis

EJ Kraaijenvanger, TM Pollok, M Monninger… - Neuroscience & …, 2020 - Elsevier
The detrimental impact of early life adversities (ELAs; entailing pre-and postnatal
experiences) on the developing brain has been well established. By inducing neural …

[HTML][HTML] Sex-specific behavioral outcomes of early-life adversity and emerging microglia-dependent mechanisms

MM Garvin, JL Bolton - Frontiers in behavioral neuroscience, 2022 - frontiersin.org
Early-life adversity (ELA) is known to alter brain circuit maturation as well as increase
vulnerability to cognitive and emotional disorders. However, the importance of examining …

[HTML][HTML] The effects of early life adversity on children's mental health and cognitive functioning

M Wade, L Wright, KE Finegold - Translational Psychiatry, 2022 - nature.com
Emerging evidence suggests that partially distinct mechanisms may underlie the association
between different dimensions of early life adversity (ELA) and psychopathology in children …