[HTML][HTML] DNA methylation age of blood predicts all-cause mortality in later life
Background DNA methylation levels change with age. Recent studies have identified
biomarkers of chronological age based on DNA methylation levels. It is not yet known …
biomarkers of chronological age based on DNA methylation levels. It is not yet known …
[HTML][HTML] DNA methylation-based measures of biological age: meta-analysis predicting time to death
Estimates of biological age based on DNA methylation patterns, often referred to as
“epigenetic age”,“DNAm age”, have been shown to be robust biomarkers of age in humans …
“epigenetic age”,“DNAm age”, have been shown to be robust biomarkers of age in humans …
[HTML][HTML] Epigenetic age acceleration predicts cancer, cardiovascular, and all-cause mortality in a German case cohort
L Perna, Y Zhang, U Mons, B Holleczek, KU Saum… - Clinical …, 2016 - Springer
Background Previous studies have developed models predicting methylation age from DNA
methylation in blood and other tissues (epigenetic clock) and suggested the difference …
methylation in blood and other tissues (epigenetic clock) and suggested the difference …
[HTML][HTML] An epigenome-wide association study of sex-specific chronological ageing
Background Advanced age is associated with cognitive and physical decline and is a major
risk factor for a multitude of disorders. There is also a gap in life expectancy between males …
risk factor for a multitude of disorders. There is also a gap in life expectancy between males …
[HTML][HTML] Dynamic DNA methylation during aging: a “prophet” of age-related outcomes
FH Xiao, HT Wang, QP Kong - Frontiers in genetics, 2019 - frontiersin.org
The biological markers of aging used to predict physical health status in older people are of
great interest. Telomere shortening, which occurs during the process of cell replication, was …
great interest. Telomere shortening, which occurs during the process of cell replication, was …
[HTML][HTML] The epigenetic clock as a predictor of disease and mortality risk: a systematic review and meta-analysis
Background Ageing is one of the principal risk factors for many chronic diseases. However,
there is considerable between-person variation in the rate of ageing and individual …
there is considerable between-person variation in the rate of ageing and individual …
DNA methylation age is associated with mortality in a longitudinal Danish twin study
An epigenetic profile defining the DNA methylation age (DNA m age) of an individual has
been suggested to be a biomarker of aging, and thus possibly providing a tool for …
been suggested to be a biomarker of aging, and thus possibly providing a tool for …
Methylation‐based estimated biological age and cardiovascular disease
L Lind, E Ingelsson, J Sundström… - European Journal of …, 2018 - Wiley Online Library
Background DNA methylation changes over life at specific sites in the genome, which can
be used to estimate “biological age.” The aim of this population‐based longitudinal cohort …
be used to estimate “biological age.” The aim of this population‐based longitudinal cohort …
A systematic review and meta-analysis of environmental, lifestyle, and health factors associated with DNA methylation age
J Ryan, J Wrigglesworth, J Loong… - The Journals of …, 2020 - academic.oup.com
DNA methylation (DNAm) algorithms of biological age provide a robust estimate of an
individual's chronological age and can predict their risk of age-related disease and mortality …
individual's chronological age and can predict their risk of age-related disease and mortality …
DNA methylation and healthy human aging
The process of aging results in a host of changes at the cellular and molecular levels, which
include senescence, telomere shortening, and changes in gene expression. Epigenetic …
include senescence, telomere shortening, and changes in gene expression. Epigenetic …