Purpose: DNA methylation alterations have emerged as front-runners in cell-free DNA
(cfDNA) biomarker development. However, much effort to date has focused on single …

Screening for early‐stage disease is vital for reducing colorectal cancer (CRC)‐related
mortality. Methylation of circulating tumor DNA has been previously used for various types of …

Purpose: Gastric adenocarcinoma is the third most common cause of cancer mortality
worldwide. Accurate and affordable noninvasive detection methods have potential value for …

Background Colorectal polyp is known a precursor of colorectal cancer (CRC) that holds an
increased risk for progression to CRC. Circulating cell-free DNA (cfDNA) methylation has …

DNA methylation plays a crucial role in tumorigenesis and tumor progression, sparking
substantial interest in the clinical applications of cancer DNA methylation biomarkers …

Background There is an increasing demand for accurate biomarkers for early non-invasive
colorectal cancer detection. We employed a genome-scale marker discovery method to …

Abstract Background Target gastrointestinal cancers (GICs), encompassing esophageal
cancer (EC), gastric cancer (GC), and colorectal cancer (CRC), originate within a single …

As one of the most malicious cancers, pancreatic cancer is difficult to treat due to the lack of
effective early diagnosis. Therefore, it is urgent to find reliable diagnostic and predictive …

Early diagnosis of colorectal cancer (CRC) is of high importance as prognosis depends on
tumour stage at the time of diagnosis. Detection of tumour-specific DNA methylation marks in …

Abnormal DNA methylation is a major early contributor to colon cancer (COAD)
development. We conducted a cohort-based systematic investigation of genome-wide DNA …