Cellular metabolism is at the foundation of all biological activities. The catabolic processes
that support cellular bioenergetics and survival have been well studied. By contrast, how …

Stem and progenitor cells proliferate and give rise to other types of cells through
differentiation. Deregulation of this process can lead to many diseases including cancer …

An understanding of metabolic pathways based solely on biochemistry textbooks would
underestimate the pervasive role of metabolism in essentially every aspect of biology. It is …

The relationship between metabolism and cell cycle progression is complex and
bidirectional. Cells must rewire metabolism to meet changing biosynthetic demands across …

Mammalian cells require growth-factor-receptor-initiated signaling to proliferate. Signal
transduction not only initiates entry into the cell cycle, but also reprograms cellular …

Tumors reprogram pathways of nutrient acquisition and metabolism to meet the
bioenergetic, biosynthetic, and redox demands of malignant cells. These reprogrammed …

ABSTRACT A defining hallmark of cancer is uncontrolled cell proliferation. This is initiated
once cells have accumulated alterations in signaling pathways that control metabolism and …

The study of normal mammalian cell growth and the defects that contribute to disease
pathogenesis links metabolism to cell growth. Here, we visit several aspects of growth …

Adaptation of cellular function with the nutrient environment is essential for survival. Failure
to adapt can lead to cell death and/or disease. Indeed, energy metabolism alterations are a …

The uptake and metabolism of nutrients support fundamental cellular process from
bioenergetics to biomass production and cell fate regulation. While many studies of cell …