Advanced age is associated with an increased susceptibility to Coronavirus Disease
(COVID)-19 and more severe outcomes, although the underlying mechanisms are …

Abstract The coronavirus disease 2019 (COVID-19), caused by the novel severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), remains to spread worldwide. COVID-19 …

Thrombosis is the major cause of death in severe acute respiratory syndrome coronavirus 2
(SARS‐CoV‐2) infection, and the pathology of vascular endothelial cells (ECs) has received …

Airway epithelial cells represent the main target of SARS-CoV-2 replication but several
pieces of evidence suggest that endothelial cells (ECs), lining pulmonary blood vessels, are …

Thrombotic and microvascular complications are frequently seen in deceased COVID-19
patients, suggesting that vascular pathology is a major driver of severe disease. However …

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the causative agent of
coronavirus disease 2019 (COVID-19), a global pandemic characterized by an exaggerated …

Rationale: Pulmonary vascular endotheliitis, perivascular inflammation, and immune
activation are observed in COVID-19 patients. While the initial SARS-CoV-2 infection mainly …

Rationale SARS-CoV-2 infection of the respiratory system can progress to a life threatening
multi-systemic disease, mediated via an excess of cytokines (“cytokine storm”), but the …

Morbidity and mortality in response to SARS-CoV-2 infection are significantly elevated in
people of advanced age. To understand the underlying biology of this phenotype, we utilize …

SARS-CoV-2 infection can cause fatal inflammatory lung pathology, including thrombosis
and increased pulmonary vascular permeability leading to edema and hemorrhage. In …