Cellular senescence has emerged as a potent tumor suppression mechanism that restrains
proliferation of cells at risk for malignant transformation. Although senescent cells have …

Cellular senescence is an established tumour-suppressive mechanism that prevents the
proliferation of premalignant cells. However, several lines of evidence show that senescent …

Cancer is a devastating disease that increases exponentially with age. Cancer arises from
cells that proliferate in an unregulated manner, an attribute that is countered by cellular …

Cellular senescence, which is associated with aging, is a process by which cells enter a
state of permanent cell cycle arrest, therefore constituting a potent tumor suppressive …

Cellular senescence is a state of durable cell arrest that has been identified both in vitro and
in vivo. It is associated with profound changes in gene expression and a specific secretory …

Simple Summary Cellular senescence consists of a permanent block of cell proliferation in
the presence of an active metabolism. It is a physiological process occurring when cells …

Senescent cells are found to accumulate in aged individuals, as well as in cancer patients
that receive chemotherapeutic treatment. Although originally believed to halt cancer …

Cellular senescence refers to a state of irreversible cell cycle arrest that can be induced by
various cellular stresses and is known to play a pivotal role in tumour suppression. While …

Simple Summary A fundamental feature of cellular senescence is the emergence of the
Senescence-Associated Secretory Phenotype (SASP), which represents a considerable …

Cellular senescence is a tumor-suppressive mechanism that permanently arrests cells at
risk for malignant transformation. However, accumulating evidence shows that senescent …