SARS‐CoV‐2 targets neurons of 3D human brain organoids

A Ramani, L Müller, PN Ostermann, E Gabriel… - The EMBO …, 2020 - embopress.org
COVID‐19 pandemic caused by SARS‐CoV‐2 infection is a public health emergency.
COVID‐19 typically exhibits respiratory illness. Unexpectedly, emerging clinical reports …

[PDF][PDF] SARS-CoV-2 targets glial cells in human cortical organoids

CL McMahon, H Staples, M Gazi, R Carrion, J Hsieh - Stem Cell Reports, 2021 - cell.com
Summary Coronavirus disease 2019 (COVID-19) patients have manifested a variety of
neurological complications, and there is still much to reveal regarding the neurotropism of …

Infection of brain organoids and 2D cortical neurons with SARS-CoV-2 pseudovirus

SA Yi, KH Nam, J Yun, D Gim, D Joe, YH Kim, HJ Kim… - Viruses, 2020 - mdpi.com
Since the global outbreak of SARS-CoV-2 (COVID-19), infections of diverse human organs
along with multiple symptoms continue to be reported. However, the susceptibility of the …

[PDF][PDF] SARS-CoV-2 infects neurons and induces neuroinflammation in a non-human primate model of COVID-19

D Beckman, A Bonillas, GB Diniz, S Ott, JW Roh… - Cell reports, 2022 - cell.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiologic agent of
coronavirus disease 2019 (COVID-19), can induce a plethora of neurological complications …

[HTML][HTML] SARS-CoV-2 infects brain astrocytes of COVID-19 patients and impairs neuronal viability

F Crunfli, VC Carregari, FP Veras, PH Vendramini… - MedRxiv, 2021 - medrxiv.org
One increasingly documented tendency of COVID-19 patients is to exhibit neuropsychiatric
and neurological symptoms. Here we found that anxiety and cognitive impairment are …

SARS-CoV-2 infects human brain organoids causing cell death and loss of synapses that can be rescued by treatment with Sofosbuvir

P Mesci, JS de Souza, L Martin-Sancho, A Macia… - PLoS …, 2022 - journals.plos.org
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the causative
agent of coronavirus disease 2019 (COVID-19), which was rapidly declared a pandemic by …

Neuroinvasion of SARS-CoV-2 in human and mouse brain

E Song, C Zhang, B Israelow, A Lu-Culligan… - Journal of Experimental …, 2021 - rupress.org
Although COVID-19 is considered to be primarily a respiratory disease, SARS-CoV-2 affects
multiple organ systems including the central nervous system (CNS). Yet, there is no …

SARS-CoV-2 promotes microglial synapse elimination in human brain organoids

n Samudyata, AO Oliveira, S Malwade… - Molecular …, 2022 - nature.com
Neuropsychiatric manifestations are common in both the acute and post-acute phase of
SARS-CoV-2 infection, but the mechanisms of these effects are unknown. In a newly …

Morphological, cellular, and molecular basis of brain infection in COVID-19 patients

F Crunfli, VC Carregari, FP Veras… - Proceedings of the …, 2022 - National Acad Sciences
Although increasing evidence confirms neuropsychiatric manifestations associated mainly
with severe COVID-19 infection, long-term neuropsychiatric dysfunction (recently …

SARS-CoV-2 invades cognitive centers of the brain and induces Alzheimer's-like neuropathology

WB Shen, M Elahi, J Logue, P Yang, L Baracco… - BioRxiv, 2022 - biorxiv.org
The neurotropism of SARS-CoV-2 and the phenotypes of infected neurons are still in
debate. Long COVID manifests with “brain diseases” and the cause of these brain …