The identification of genes and interventions that slow or reverse aging is hampered by the
lack of non-invasive metrics that can predict the life expectancy of pre-clinical models. Frailty …

Although survival has been the focus of aging research for many years, the field is rapidly
evolving towards incorporating healthspan and health indices in studies that explore aging …

The aging process results in multiple traceable footprints, which can be quantified and used
to estimate an organism's age. Examples of such aging biomarkers include epigenetic …

Aging clocks dissociate biological from chronological age. The estimation of biological age
is important for identifying gerontogenes and assessing environmental, nutritional, or …

Current concepts regarding the biology of aging are primarily based on studies aimed at
identifying factors regulating lifespan. However, lifespan as a sole proxy measure for aging …

Epigenetic clocks, developed using DNA methylation data, have been widely used to
quantify biological aging in multiple tissues/cells. However, many existing epigenetic clocks …

The development of healthspan-extending pharmaceuticals requires quantitative estimation
of age-related progressive physiological decline. In humans, individual health status can be …

Genetic factors clearly contribute to exceptional longevity and healthy aging in humans, yet
the identification of the underlying genes remains a challenge. Longevity is a complex …

This article investigates the effect on the mouse frailty index (FI), of factors known to
influence lifespan and healthspan in mice: strain (short-lived DBA/2J mice vs long-lived …

Human DNA-methylation data have been used to develop highly accurate biomarkers of
aging (" epigenetic clocks"). Recent studies demonstrate that similar epigenetic clocks for …