Ample evidence from model organisms has indicated that subtle variation in genes can
dramatically influence lifespan. The key genes and molecular pathways that have been …

The notion of frailty has evolved for more than 15 years. Although there is no consensus
definition, frailty reflects a state of increased vulnerability to adverse health outcomes for …

Frailty is a state of high vulnerability to adverse health outcomes. This concept is used to
explain the heterogeneity in rates of aging in people of the same age. Frailty has important …

Frailty is a multiply determined, age-related state of increased risk for adverse health
outcomes. We review how the degree of frailty conditions the development of late-life …

Epigenetic alterations pose one major hallmark of organismal aging. Here, we provide an
overview on recent findings describing the epigenetic changes that arise during aging and …

First published in 2016, predictors of chronological and biological age developed using
deep learning (DL) are rapidly gaining popularity in the aging research community. These …

Modern machine learning techniques (such as deep learning) offer immense opportunities
in the field of human biological aging research. Aging is a complex process, experienced by …

Advanced age is the main common risk factor for cancer, cardiovascular disease and
neurodegeneration. Yet, more is known about the molecular basis of any of these groups of …

Although many common diseases occur mostly in old age, the impact of ageing itself on
disease risk and expression often goes unevaluated. To consider the impact of ageing …

Frailty is increasingly relevant for clinicians to improve care for vulnerable older adults.
Prominent frailty measures include the frailty phenotype and the frailty index. The frailty …