The development of 'age clocks', machine learning models predicting age from biological
data, has been a major milestone in the search for reliable markers of biological age and …

Population aging is an international concern, in part because of consequences of coming
age-structure changes, eg, growth in the number of elderly, decline in the number of youth …

Even though they would have great benefit across research and clinical fields, currently
there are no accepted biomarkers of frailty. Cross-sectional studies in humans have …

We present the AGEMAP (Atlas of Gene Expression in Mouse Aging Project) gene
expression database, which is a resource that catalogs changes in gene expression as a …

As a complicated process, aging is characterized by various changes at the cellular,
subcellular and nuclear levels, one of which is epigenetic aging. With increasing awareness …

The applications of modern artificial intelligence (AI) algorithms within the field of aging
research offer tremendous opportunities. Aging is an almost universal unifying feature …

Mammals differ more than 100-fold in maximum lifespan. Here, we conducted comparative
transcriptomics on 26 species with diverse lifespans. We identified thousands of genes with …

Background The relationship between age-related frailty and the underlying processes that
drive changes in health is currently unclear. Considered individually, most blood biomarkers …

Some humans age faster than others. Variation in biological aging can be measured in
midlife, but the implications of this variation are poorly understood. We tested associations …

Frailty has long been an important concept in the practice of geriatric medicine and in
gerontological research, but integration and implementation of frailty concepts into clinical …