Background The trajectory of frailty in older adults is important to public health; therefore,
markers that may help predict this and other important outcomes could be beneficial …

Aging negatively impacts vitality and health. Many genetic pathways that regulate aging
were discovered in invertebrates. However, the genetics of aging is more complex in …

We previously quantified frailty in aged mice with frailty index (FI) that used specialized
equipment to measure health parameters. Here we developed a simplified, noninvasive …

Objective Use of the frailty index to measure an accumulation of deficits has been proven a
valuable method for identifying elderly people at risk for increased vulnerability, disease …

Biological ageing and its mechanistic underpinnings are of immense biomedical and
ecological significance. Ageing involves the decline of diverse biological functions and …

The Geoscience paradigm suggests that targeting the aging process could delay or prevent
the risk of multiple major age-related diseases, such as cancer, cardiovascular disease …

Benchmarks for ageing studies | Nature Skip to main content Thank you for visiting nature.com.
You are using a browser version with limited support for CSS. To obtain the best experience …

Limiting the debilitating consequences of ageing is a major medical challenge of our time.
Robust pharmacological interventions that promote healthy ageing across diverse genetic …

The development of animal models to study human frailty is important to test interventions to
be translated to the clinical practice. The aim of this work was to develop a score for frailty in …

Frailty is a common geriatric syndrome and strongly associated with disability, mortality and
hospitalization. Frailty is commonly measured using the frailty index (FI), based on the …