Recent progress in the science of aging is driven largely by the use of model systems,
ranging from yeast and nematodes to mice. These models have revealed conservation in …

Recent discoveries in the science of ageing indicate that lifespan in model organisms such
as yeast, nematodes, flies and mice is plastic and can be manipulated by genetic, nutritional …

When the food intake of organisms such as yeast and rodents is reduced (dietary restriction),
they live longer than organisms fed a normal diet. A similar effect is seen when the activity of …

Until recently, biogerontology was a backwater of biology, but progress in the qualitative and
quantitative genetic analysis of longevity has led to a revolution in aging research. This …

Loss of genome maintenance may causally contribute to ageing, as exemplified by the
premature appearance of multiple symptoms of ageing in a growing family of human …

For several decades, understanding ageing and the processes that limit lifespan have
challenged biologists. Thirty years ago, the biology of ageing gained unprecedented …

Research on longevity and healthy aging promises to increase our lifespan and decrease
the burden of degenerative diseases with important social and economic effects. Many …

Ample evidence from model organisms has indicated that subtle variation in genes can
dramatically influence lifespan. The key genes and molecular pathways that have been …

The field of aging research has progressed rapidly over the past few decades. Genetic
modulators of aging rate that are conserved over a broad evolutionary distance have now …

Epigenetic clocks are mathematically derived age estimators that are based on
combinations of methylation values that change with age at specific CpGs in the genome …