DNA damage and telomere dysfunction shorten organismal lifespan. Here we show that oral
glucose administration at advanced age increases health and lifespan of telomere …

A hallmark of ageing is dysfunction in nutrient signalling pathways that regulate glucose
homeostasis, negatively affecting whole-body energy metabolism and ultimately increasing …

Mitochondria play essential roles in metabolic support and signaling within all cells.
Congenital and acquired defects in mitochondria are responsible for several pathologies …

Cellular senescence is an irreversible cell arrest process, which is determined by a variety of
complicated mechanisms, including telomere attrition, mitochondrial dysfunction, metabolic …

Telomere dysfunction activates p53-mediated cellular growth arrest, senescence and
apoptosis to drive progressive atrophy and functional decline in high-turnover tissues. The …

Background Caloric restriction is known to extend the lifespan of all organisms in which it
has been tested. Consequently, current research is investigating the role of various foods to …

Mitochondrial dysfunction and oxidative stress have been implicated in cellular senescence,
apoptosis, aging and aging‐associated pathologies. Telomere shortening and genomic …

Caloric restriction, leanness and decreased activity of insulin/insulin‐like growth factor 1
(IGF‐1) receptor signaling are associated with increased longevity in a wide range of …

Common observation, bolstered by a wealth of epidemiologic evidence, demonstrates that
aging is accompanied by a profound increase in the incidence of cardiovascular disease …

Telomeres and mitochondria are known to deteriorate over time. Telomere shortening is
associated with aging, early senescence, and premature cell death. Mitochondrial …