[HTML][HTML] Deep aging clocks: the emergence of AI-based biomarkers of aging and longevity

A Zhavoronkov, P Mamoshina - Trends in Pharmacological Sciences, 2019 - cell.com
First published in 2016, predictors of chronological and biological age developed using
deep learning (DL) are rapidly gaining popularity in the aging research community. These …

[HTML][HTML] Deep biomarkers of aging and longevity: from research to applications

A Zhavoronkov, R Li, C Ma, P Mamoshina - Aging (Albany NY), 2019 - ncbi.nlm.nih.gov
Multiple recent advances in machine learning enabled computer systems to exceed human
performance in many tasks including voice, text, and speech recognition and complex …

Assessing the rate of aging to monitor aging itself

X Xia, Y Wang, Z Yu, J Chen, JDJ Han - Ageing Research Reviews, 2021 - Elsevier
Healthy aging is the prime goal of aging research and interventions. Healthy aging or not
can be quantified by biological aging rates estimated by aging clocks. Generation and …

Population specific biomarkers of human aging: a big data study using South Korean, Canadian, and Eastern European patient populations

P Mamoshina, K Kochetov, E Putin… - The Journals of …, 2018 - academic.oup.com
Accurate and physiologically meaningful biomarkers for human aging are key to assessing
antiaging therapies. Given ethnic differences in health, diet, lifestyle, behavior …

The protein inputs of an ultra-predictive aging clock represent viable anti-aging drug targets

AA Johnson, MN Shokhirev, B Lehallier - Ageing Research Reviews, 2021 - Elsevier
Abstract Machine learning models capable of predicting age given a set of inputs are
referred to as aging clocks. We recently developed an aging clock that utilizes 491 plasma …

Leveraging AI to identify dual-purpose aging and disease targets

GHD Leung, CW Wong, FW Pun, A Aliper… - Expert Opinion on …, 2023 - Taylor & Francis
Aging is a significant contributor to various chronic diseases, thus emerging as an
increasingly important area of research. Elucidating the mechanisms underlying aging can …

[HTML][HTML] Artificial intelligence for aging and longevity research: Recent advances and perspectives

A Zhavoronkov, P Mamoshina, Q Vanhaelen… - Ageing research …, 2019 - Elsevier
The applications of modern artificial intelligence (AI) algorithms within the field of aging
research offer tremendous opportunities. Aging is an almost universal unifying feature …

[HTML][HTML] ARDD 2020: from aging mechanisms to interventions

GV Mkrtchyan, K Abdelmohsen, P Andreux… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
Aging is emerging as a druggable target with growing interest from academia, industry and
investors. New technologies such as artificial intelligence and advanced screening …

[HTML][HTML] Towards AI-driven longevity research: an overview

N Marino, G Putignano, S Cappilli, E Chersoni… - Frontiers in …, 2023 - frontiersin.org
While in the past technology has mostly been utilized to store information about the
structural configuration of proteins and molecules for research and medical purposes …

[HTML][HTML] Biohorology and biomarkers of aging: Current state-of-the-art, challenges and opportunities

F Galkin, P Mamoshina, A Aliper… - Ageing Research …, 2020 - Elsevier
The aging process results in multiple traceable footprints, which can be quantified and used
to estimate an organism's age. Examples of such aging biomarkers include epigenetic …