Animal models of Parkinson's disease: bridging the gap between disease hallmarks and research questions

A Dovonou, C Bolduc, V Soto Linan, C Gora… - Translational …, 2023 - Springer
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by
motor and non-motor symptoms. More than 200 years after its first clinical description, PD …

Animal models of Parkinson's disease progression

GE Meredith, PK Sonsalla, MF Chesselet - Acta neuropathologica, 2008 - Springer
Parkinson's disease (PD) is a progressive neurodegenerative disorder whose etiology is not
understood. This disease occurs both sporadically and through inheritance of single genes …

[HTML][HTML] Animal models of Parkinson's disease: a gateway to therapeutics?

W Le, P Sayana, J Jankovic - Neurotherapeutics, 2014 - Elsevier
Parkinson's disease (PD) is a progressive, neurodegenerative disorder of unknown etiology,
although a complex interaction between environmental and genetic factors has been …

Animal models of Parkinson's disease: An updated overview

P Gubellini, P Kachidian - Revue neurologique, 2015 - Elsevier
Parkinson's disease (PD) is a progressive neurodegenerative disorder whose etiology,
besides a minority of genetic cases, is still largely unknown. Animal models have contributed …

Classic and evolving animal models in Parkinson's disease

T Pingale, GL Gupta - Pharmacology Biochemistry and Behavior, 2020 - Elsevier
Parkinson's disease (PD) is a progressive neurodegenerative disease with motor and non-
motor symptoms. PD is characterized by the degeneration of dopaminergic neurons in the …

[HTML][HTML] Animal models of PD: pieces of the same puzzle?

TM Dawson, AS Mandir, MK Lee - Neuron, 2002 - cell.com
Parkinson's disease (PD) is a common neurodegenerative disorder with no known cure. The
etiology of PD is likely due, in part, to combinations of genetic susceptibilities and …

Classic and new animal models of Parkinson′ s disease

J Blesa, S Phani, V Jackson-Lewis… - BioMed Research …, 2012 - Wiley Online Library
Neurological disorders can be modeled in animals so as to recreate specific pathogenic
events and behavioral outcomes. Parkinson's Disease (PD) is the second most common …

Animal models of Parkinson's disease: are they useful or not?

RA Barker, A Björklund - Journal of Parkinson's Disease, 2020 - content.iospress.com
The use of animal models in Parkinson's disease research has been controversial in terms
of how well they relate to the clinical condition and thus their utility for translating therapies …

Parkinson's disease: a rethink of rodent models

HL Melrose, SJ Lincoln, GM Tyndall… - Experimental Brain …, 2006 - Springer
Parkinson's disease (PD) is a multifactorial disease with a complex etiology that results from
genetic risk factors, environmental exposures and most likely a combination of both. Rodent …

Animal models of Parkinson's disease: a guide to selecting the optimal model for your research

J Lama, Y Buhidma, EJR Fletcher, S Duty - Neuronal Signaling, 2021 - portlandpress.com
Parkinson's disease (PD) is a complex, multisystem disorder characterised by α-synuclein
(SNCA) pathology, degeneration of nigrostriatal dopaminergic neurons, multifactorial …