Exploring the relevance of senotherapeutics for the current SARS-CoV-2 emergency and similar future global health threats
The higher death rate caused by COVID-19 in older people, especially those with
comorbidities, is a challenge for biomedical aging research. Here we explore the idea that …
comorbidities, is a challenge for biomedical aging research. Here we explore the idea that …
Cellular senescence as a potential mediator of COVID‐19 severity in the elderly
J Nehme, M Borghesan, S Mackedenski, TG Bird… - Aging cell, 2020 - Wiley Online Library
SARS‐CoV‐2 is a novel betacoronavirus which infects the lower respiratory tract and can
cause coronavirus disease 2019 (COVID‐19), a complex respiratory distress syndrome …
cause coronavirus disease 2019 (COVID‐19), a complex respiratory distress syndrome …
COVID‐19 is an emergent disease of aging
COVID‐19 is an ongoing pandemic caused by the SARS‐CoV‐2 coronavirus that poses one
of the greatest challenges to public health in recent years. SARS‐CoV‐2 is known to …
of the greatest challenges to public health in recent years. SARS‐CoV‐2 is known to …
COVID-19 and crosstalk with the hallmarks of aging
Within the past several decades, the emergence of new viral diseases with severe health
complications and mortality is evidence of an age-dependent, compromised bodily response …
complications and mortality is evidence of an age-dependent, compromised bodily response …
COVID-19 therapeutics: Challenges and directions for the future
PC Robinson, DFL Liew, HL Tanner… - Proceedings of the …, 2022 - National Acad Sciences
The emergence of SARS-CoV-2 triggering the COVID-19 pandemic ranks as arguably the
greatest medical emergency of the last century. COVID-19 has highlighted health disparities …
greatest medical emergency of the last century. COVID-19 has highlighted health disparities …
[HTML][HTML] Why does COVID-19 disproportionately affect older people?
AL Mueller, MS McNamara, DA Sinclair - Aging (albany NY), 2020 - ncbi.nlm.nih.gov
The severity and outcome of coronavirus disease 2019 (COVID-19) largely depends on a
patient's age. Adults over 65 years of age represent 80% of hospitalizations and have a 23 …
patient's age. Adults over 65 years of age represent 80% of hospitalizations and have a 23 …
Treatment with the senolytics dasatinib/quercetin reduces SARS‐CoV‐2‐related mortality in mice
A Pastor‐Fernández, AR Bertos, A Sierra‐Ramírez… - Aging …, 2023 - Wiley Online Library
The enormous societal impact of the ongoing COVID‐19 pandemic has been particularly
harsh for some social groups, such as the elderly. Recently, it has been suggested that …
harsh for some social groups, such as the elderly. Recently, it has been suggested that …
Emerging therapeutic approaches to combat COVID-19: present status and future perspectives
K Vivekanandhan, P Shanmugam… - Frontiers in Molecular …, 2021 - frontiersin.org
Coronavirus disease (COVID-19) has emerged as a fast-paced epidemic in late 2019 which
is disrupting life-saving immunization services. SARS-CoV-2 is a highly transmissible virus …
is disrupting life-saving immunization services. SARS-CoV-2 is a highly transmissible virus …
COVID-19 and cellular senescence
CA Schmitt, T Tchkonia, LJ Niedernhofer… - Nature Reviews …, 2023 - nature.com
The clinical severity of coronavirus disease 2019 (COVID-19) is largely determined by host
factors. Recent advances point to cellular senescence, an ageing-related switch in cellular …
factors. Recent advances point to cellular senescence, an ageing-related switch in cellular …
Tackling SARS-CoV-2: proposed targets and repurposed drugs
The SARS-CoV-2 pandemic, declared as a global health emergency by the WHO in
February 2020, has currently infected more than 6 million people with fatalities near 371,000 …
February 2020, has currently infected more than 6 million people with fatalities near 371,000 …