Background There is an increasing demand for accurate biomarkers for early non-invasive
colorectal cancer detection. We employed a genome-scale marker discovery method to …

DNA methylation biomarkers for noninvasive diagnosis of colorectal cancer (CRC) and
precursor lesions have been extensively studied. Different panels have been reported …

Background Early detection plays an essential role to reduce colorectal cancer (CRC)
mortality. While current screening methods suffer from poor compliance, liquid biopsy-based …

Colorectal cancer (CRC) is the second leading cause of cancer death worldwide that is
attributed to gradual long‐term accumulation of both genetic and epigenetic changes. To …

Since genetic and epigenetic alterations influence the development of colorectal cancer
(CRC), huge potential lies in the use of DNA methylation as biomarkers to improve the …

Background Aberrant DNA hypermethylation of CpG islands (CGIs) occurs frequently and is
genome-wide in human gastric cancer (GC). A DNA methylation approach in plasma cell …

Rational: LDCT screening can identify early-stage lung cancers yet introduces excessive
false positives and it remains a great challenge to differentiate malignant tumors from benign …

Abstract Background Circulating tumour DNA (ctDNA) has emerged as an excellent
candidate for the future of liquid biopsies for many cancers. There has been growing interest …

Tumor-derived circulating cell-free DNA (cfDNA) provides critical clues for cancer early
diagnosis, yet it often suffers from low sensitivity. Here, we present a cancer early diagnosis …

Colorectal cancer (CRC) is the second leading cause for cancer-related death globally.
Clinically, there is an urgent need for non-invasive CRC detection. This study assessed the …