Purpose: DNA methylation alterations have emerged as front-runners in cell-free DNA
(cfDNA) biomarker development. However, much effort to date has focused on single …

Background Abnormal DNA methylation is a hallmark of human cancers and may be a
promising biomarker for early diagnosis of human cancers. However, the majority of DNA …

The low abundance of circulating tumour DNA (ctDNA) in plasma samples makes the
analysis of ctDNA biomarkers for the detection or monitoring of early-stage cancers …

Background Colorectal cancer (CRC) screening is the most efficient strategy to reduce
disease-related mortality. Frequent aberrant DNA methylation is known to occur in selected …

Lung, breast, colorectal, and prostate cancers are the most incident worldwide. Optimal
population-based cancer screening methods remain an unmet need, since cancer detection …

Colorectal cancer (CRC) is one of the most common cancer worldwide and results from the
accumulation of mutations and epimutations in colonic mucosa cells ultimately leading to …

Objective Mutations in cell-free circulating DNA (cfDNA) have been studied for tracking
disease relapse in colorectal cancer (CRC). This approach requires personalised assay …

Background Colorectal cancer (CRC) is one of the most common cancers in the western
world. Screening is an efficient method of reducing cancer-related mortality. Molecular …

Background Methylation plays an important role in the etiology and pathogenesis of
colorectal cancer (CRC). This study aimed to identify aberrantly methylated-differentially …

DNA methylation profiles are in dynamic equilibrium via the initiation of methylation,
maintenance of methylation and demethylation, which control gene expression and …