Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity
Background Identification of genes that modulate longevity is a major focus of aging-related
research and an area of intense public interest. In addition to facilitating an improved …
research and an area of intense public interest. In addition to facilitating an improved …
A meta-analysis of genome-wide association studies identifies multiple longevity genes
Human longevity is heritable, but genome-wide association (GWA) studies have had limited
success. Here, we perform two meta-analyses of GWA studies of a rigorous longevity …
success. Here, we perform two meta-analyses of GWA studies of a rigorous longevity …
Buffering mechanisms in aging: a systems approach toward uncovering the genetic component of aging
An unrealized potential to understand the genetic basis of aging in humans, is to consider
the immense survival advantage of the rare individuals who live 100 years or more. The …
the immense survival advantage of the rare individuals who live 100 years or more. The …
The genetic component of human longevity: New insights from the analysis of pathway‐based SNP‐SNP interactions
In human longevity studies, single nucleotide polymorphism (SNP) analysis identified a
large number of genetic variants with small effects, yet not easily replicable in different …
large number of genetic variants with small effects, yet not easily replicable in different …
Longevity network: construction and implications
A Budovsky, A Abramovich, R Cohen… - Mechanisms of ageing …, 2007 - Elsevier
The vast majority of studies on longevity have focused on individual genes/proteins, without
adequately addressing the possible role of interactions between them. This study is the first …
adequately addressing the possible role of interactions between them. This study is the first …
Integrated genetic analyses revealed novel human longevity loci and reduced risks of multiple diseases in a cohort study of 15,651 Chinese individuals
There is growing interest in studying the genetic contributions to longevity, but limited
relevant genes have been identified. In this study, we performed a genetic association study …
relevant genes have been identified. In this study, we performed a genetic association study …
Quantitative evidence for conserved longevity pathways between divergent eukaryotic species
ED Smith, M Tsuchiya, LA Fox, N Dang, D Hu… - Genome …, 2008 - genome.cshlp.org
Studies in invertebrate model organisms have been a driving force in aging research,
leading to the identification of many genes that influence life span. Few of these genes have …
leading to the identification of many genes that influence life span. Few of these genes have …
Inferring the functions of longevity genes with modular subnetwork biomarkers of Caenorhabditis elegansaging
A central goal of biogerontology is to identify robust gene-expression biomarkers of aging.
Here we develop a method where the biomarkers are networks of genes selected based on …
Here we develop a method where the biomarkers are networks of genes selected based on …
Why genes extending lifespan in model organisms have not been consistently associated with human longevity and what it means to translation research
JP de Magalhaes - Cell Cycle, 2014 - Taylor & Francis
A recent paper by Deelen et al.(2014) in Human Molecular Genetics reports the largest
genome-wide association study of human longevity to date. While impressive, there is a …
genome-wide association study of human longevity to date. While impressive, there is a …
Genome‐wide linkage analysis for human longevity: Genetics of Healthy Aging Study
Clear evidence exists for heritability of human longevity, and much interest is focused on
identifying genes associated with longer lives. To identify such longevity alleles, we …
identifying genes associated with longer lives. To identify such longevity alleles, we …