Importance Adverse childhood experiences (ACEs) are associated with the risk of poorer
health, and identifying molecular mechanisms may lay the foundation for health promotion in …

Epigenetic biomarkers of accelerated aging have been widely used to predict disease risk
and may enhance our understanding of biological mechanisms between early-life adversity …

Importance Child physical and emotional abuse and neglect may affect epigenetic
signatures of accelerated aging several years after the exposure. Objective To examine the …

Research examining the association between exposure to a wide range of adverse
childhood experiences (ACEs) and accelerated biological aging in older adults is limited …

Importance Epigenetic age acceleration is associated with exposure to social and economic
adversity and may increase the risk of premature morbidity and mortality. However, no …

Importance Adverse childhood experiences (ACEs), potentially traumatic experiences
occurring before the age of 18 years, are associated with epigenetic aging later in life and …

Background Longitudinal studies are needed to clarify whether early adversities are
associated with advanced methylation age or if they actually accelerate methylation aging …

Importance Accelerated biological aging is associated with decreased physical capability
and cognitive functioning, which are associated with increased risk of morbidity and …

Emerging research suggests associations of physical and psychosocial stressors with
epigenetic aging. Although this work has included early-life exposures, data on maternal …

Importance Epigenetic clocks represent molecular evidence of disease risk and aging
processes and have been used to identify how social and lifestyle characteristics are …