There is an intense search for longevity genes in both animal models and humans. Human
family studies have indicated that a modest amount of the overall variation in adult lifespan …

The heritability of human longevity was investigated in a sample of 218 pairs of monozygotic
(MZ) and 382 pairs of like-sex dizygotic (DZ) Danish twin pairs born 1870–1880. Twin …

This paper reviews the recent literature on genes and longevity. The influence of genes on
human life span has been confirmed in studies of life span correlation between related …

We review three approaches to the genetic analysis of the biology and pathobiology of
human aging. The first and so far the best-developed is the search for the biochemical …

The aim of this study was to explore, in a large and non-censored twin cohort, the nature (ie,
additive versus non-additive) and magnitude (ie, heritability) of genetic influences on inter …

Background. The relative importance of genetic influences on longevity was studied on data
from the populationbased Swedish Twin Registry. Methods. A sample of 3,656 identical and …

Longevity, ie, the property of being long-lived, has its natural limitation in the aging process.
Longevity has a strong genetic component, as has become apparent from studies with a …

Ample evidence from model organisms has indicated that subtle variation in genes can
dramatically influence lifespan. The key genes and molecular pathways that have been …

Many of the genes that affect aging and longevity in model organisms, such as mice, fruit
flies, and worms, have human homologs. This article reviews several genetic pathways that …

Aging is due to a complex interaction of genetic, epigenetic, and environmental factors, but a
strong genetic component appears to have an impact on survival to extreme ages. In order …