Our understanding of the mechanisms by which aging is produced is still very limited. Here,
we have determined the sera metabolite profile of 117 wild‐type mice of different genetic …

After humans, mice are the best-studied mammalian species in terms of their biology and
genetics. Gerontological research has used mice and rats extensively to generate short-and …

Aging is characterized by a general decline in cellular function, which ultimately will affect
whole body homeostasis. Although DNA damage and oxidative stress all contribute to …

Telomere dynamics have been found to be better predictors of survival and mortality than
chronological age. Telomeres, the caps that protect the end of linear chromosomes, are …

The mouse has rapidly become the mammalian model organism of choice in ageing
research due to its relatively short lifespan, the proximity of its genome and physiology to …

A major goal in aging research is to improve health during aging. In the case of mice,
genetic manipulations that shorten or lengthen telomeres result, respectively, in decreased …

Caloric restriction (CR), a reduction of food intake while avoiding malnutrition, can delay the
onset of cancer and age-related diseases in several species, including mice. In addition …

Mouse-sized naked mole-rats (Heterocephalus glaber), unlike other mammals, do not
conform to Gompertzian laws of age-related mortality; adults show no age-related change in …

Telomerase is repressed in the majority of human somatic tissues. As a result human
somatic cells undergo replicative senescence, which plays an important role in suppressing …

The dysregulation of cellular metabolism is a hallmark of ageing. To understand the
metabolic changes that occur as a consequence of the ageing process and to find …