[HTML][HTML] The impact of mutations in SARS-CoV-2 spike on viral infectivity and antigenicity

Q Li, J Wu, J Nie, L Zhang, H Hao, S Liu, C Zhao… - Cell, 2020 - cell.com
The spike protein of SARS-CoV-2 has been undergoing mutations and is highly
glycosylated. It is critically important to investigate the biological significance of these …

Global variants of COVID-19: Current understanding

B Roy, JK Dhillon, N Habib… - Journal of Biomedical …, 2021 - nepjol.info
Background: SARS-CoV-2 is an RNA virus that undergoes mutation producing a variety of
strains. Mutagens include UV radiation, metals, and endogenous components of organisms …

The emerging concern and interest SARS-CoV-2 variants

E Janik, M Niemcewicz, M Podogrocki, I Majsterek… - Pathogens, 2021 - mdpi.com
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) responsible for
coronavirus disease 2019 (COVID-19) was discovered in December 2019 in Wuhan, China …

Analysis of the mutation dynamics of SARS-CoV-2 reveals the spread history and emergence of RBD mutant with lower ACE2 binding affinity

Y Jia, G Shen, S Nguyen, Y Zhang, KS Huang, HY Ho… - BioRxiv, 2020 - biorxiv.org
Monitoring the mutation dynamics of SARS-CoV-2 is critical for the development of effective
approaches to contain the pathogen. By analyzing 106 SARS-CoV-2 and 39 SARS genome …

A novel synonymous mutation of SARS-CoV-2: is this possible to affect their antigenicity and immunogenicity?

SJ Kim, VG Nguyen, YH Park, BK Park, HC Chung - Vaccines, 2020 - mdpi.com
The S glycoprotein of coronaviruses is important for viral entry and pathogenesis with most
variable sequences. Therefore, we analyzed the S gene sequences of SARS-CoV-2 to …

Evolution patterns of SARS-CoV-2: Snapshot on its genome variants

M Giovanetti, F Benedetti, G Campisi, A Ciccozzi… - Biochemical and …, 2021 - Elsevier
An acute respiratory syndrome (COVID-19), caused by a novel coronavirus (SARS-CoV-2)
with a high rate of morbidity and elevate mortality, has emerged as one of the most important …

Facing the wrath of enigmatic mutations: a review on the emergence of severe acute respiratory syndrome coronavirus 2 variants amid coronavirus disease‐19 …

J Chadha, L Khullar, N Mittal - Environmental microbiology, 2022 - Wiley Online Library
The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is an emerging
respiratory virus responsible for the ongoing coronavirus disease 19 (COVID‐19) pandemic …

SARS-CoV-2 E484K mutation narrative review: epidemiology, immune escape, clinical implications, and future considerations

WT Yang, WH Huang, TL Liao, TH Hsiao… - Infection and Drug …, 2022 - Taylor & Francis
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread rapidly over the
world and claimed million lives. The virus evolves constantly, and a swarm of mutants is a …

Characterizations of SARS-CoV-2 mutational profile, spike protein stability and viral transmission

S Laha, J Chakraborty, S Das, SK Manna… - Infection, genetics and …, 2020 - Elsevier
The recent pandemic of SARS-CoV-2 infection has affected more than 3.0 million people
worldwide with more than 200 thousand reported deaths. The SARS-CoV-2 genome has the …

The impact of receptor-binding domain natural mutations on antibody recognition of SARS-CoV-2

C Li, X Tian, X Jia, J Wan, L Lu, S Jiang, F Lan… - … and Targeted Therapy, 2021 - nature.com
The ongoing COVID-19 pandemic has resulted in over 25.0 million confirmed cases and
over 840,000 deaths globally. As the third severe respiratory disease outbreak caused by …