Background Targeted methylation sequencing of plasma cell-free DNA (cfDNA) has a
potential to expand liquid biopsies to patients with tumors without detectable oncogenic …

An effective blood-based method for the diagnosis of colorectal cancer has not yet been
developed. Molecular alterations of immune cells occur early in tumorigenesis, providing the …

Background Cell-free circulating tumour-derived DNA (ctDNA) can be detected by testing for
methylated BCAT1 and IKZF1 DNA, which has proven sensitivity for colorectal cancer …

BACKGROUND Aberrant DNA hypermethylation of CpG islands occurs frequently
throughout the genome in human colorectal cancer (CRC). A genome-wide DNA …

Aberrant DNA methylation often occurs in colorectal cancer (CRC). In our study we applied a
genome-wide DNA methylation analysis approach, MethylCap-seq, to map the differentially …

Illumina's Infinium HumanMethylation450 BeadChip arrays were used to examine genome-
wide DNA methylation profiles in 22 sample pairs from colorectal cancer (CRC) and …

Background. Colorectal cancer (CRC) is one of the leading causes of cancer deaths
worldwide and in China. Early CRC screening is the best approach to reduce its incidence …

Abnormal DNA methylation is a major early contributor to colon cancer (COAD)
development. We conducted a cohort-based systematic investigation of genome-wide DNA …

Simple Summary The role of DNA methylation in the carcinogenesis of colorectal cancer
(CRC) diagnosed< 50 years of age (early-onset CRC or EOCRC) is currently unknown. In …

Solid tumors shed DNA into circulation, and there is growing evidence that the detection of
circulating tumor DNA (ctDNA) has broad clinical utility, including monitoring of disease …