The demographic and biomedical case for late-life interventions in aging

MJ Rae, RN Butler, J Campisi, ADNJ De Grey… - Science translational …, 2010 - science.org
The social and medical costs of the biological aging process are high and will rise rapidly in
coming decades, creating an enormous challenge to societies worldwide. In recent …

Innovating aging: promises and pitfalls on the road to life extension

J Vijg, ADNJ De Grey - Gerontology, 2014 - karger.com
One of the main benefits of the dramatic technological progress over the last two centuries is
the enormous increase in human life expectancy, which has now reached record highs. After …

[图书][B] The future of aging: pathways to human life extension

GM Fahy, M West, LS Coles, SB Harris - 2010 - books.google.com
Just as the health costs of aging threaten to bankrupt developed countries, this book makes
the scientific case that a biological" bailout" could be on the way, and that human aging can …

[HTML][HTML] The road ahead for health and lifespan interventions

M Gonzalez-Freire, A Diaz-Ruiz, D Hauser… - Ageing research …, 2020 - Elsevier
Aging is a modifiable risk factor for most chronic diseases and an inevitable process in
humans. The development of pharmacological interventions aimed at delaying or preventing …

Interventions to slow aging in humans: are we ready?

VD Longo, A Antebi, A Bartke, N Barzilai… - Aging cell, 2015 - Wiley Online Library
The workshop entitled 'Interventions to Slow Aging in Humans: Are We Ready?'was held in
Erice, Italy, on October 8–13, 2013, to bring together leading experts in the biology and …

A synopsis on aging—Theories, mechanisms and future prospects

JP da Costa, R Vitorino, GM Silva, C Vogel… - Ageing research …, 2016 - Elsevier
Answering the question as to why we age is tantamount to answering the question of what is
life itself. There are countless theories as to why and how we age, but, until recently, the very …

[HTML][HTML] Translational geroscience: emphasizing function to achieve optimal longevity

DR Seals, S Melov - Aging (albany NY), 2014 - ncbi.nlm.nih.gov
Among individuals, biological aging leads to cellular and organismal dysfunction and an
increased risk of chronic degenerative diseases and disability. This sequence of events in …

Healthy aging: the ultimate preventative medicine

M Kaeberlein, PS Rabinovitch, GM Martin - Science, 2015 - science.org
Age is the greatest risk factor for nearly every major cause of mortality in developed nations.
Despite this, most biomedical research focuses on individual disease processes without …

Extending human healthspan and longevity: a symposium report

LM DeVito, N Barzilai, AM Cuervo… - Annals of the New …, 2022 - Wiley Online Library
For many years, it was believed that the aging process was inevitable and that age‐related
diseases could not be prevented or reversed. The geroscience hypothesis, however, posits …

Anti‐ageing strategies: prevention or therapy? Slowing ageing from within

SIS Rattan - EMBO reports, 2005 - embopress.org
Biogerontology—the study of the bio-logical basis of ageing—is now a mature research field
that could eventually offer effective applications to ease the burden of old age. Unlike other …