Significant difference of immune cell fractions and their correlations with differential expression genes in Parkinson's disease

Y Huang, H Liu, J Hu, C Han, Z Zhong… - Frontiers in Aging …, 2021 - frontiersin.org
Parkinson's disease (PD) is the second most neurodegenerative disease in the world. T cell
infiltration in the central nervous system (CNS) has provided insights that the peripheral …

Inflammatory blood biomarkers are associated with long-term clinical disease severity in Parkinson's disease

DH Hepp, TA van Wageningen, KL Kuiper… - International journal of …, 2023 - mdpi.com
An altered immune response has been identified as a pathophysiological factor in
Parkinson's disease (PD). We aimed to identify blood immunity-associated proteins that …

Involvement of the immune system, endocytosis and EIF2 signaling in both genetically determined and sporadic forms of Parkinson's disease

E Mutez, A Nkiliza, K Belarbi, A de Broucker… - Neurobiology of …, 2014 - Elsevier
The leucine-rich repeat kinase 2 (LRRK2) G2019S mutation is a common genetic cause of
Parkinson's disease (PD). Although patients with sporadic PD and individuals with LRRK2 …

miRNAs and target genes in the blood as biomarkers for the early diagnosis of Parkinson's disease

X Liu, J Chen, T Guan, H Yao, W Zhang, Z Guan… - BMC systems …, 2019 - Springer
Background Parkinson's disease (PD) is the second most common neurodegenerative
disease, and it is a multifactorial disease with no definite diagnostic index. The aim of this …

A broad cuproptosis landscape in inflammatory bowel disease

Y Chen, X Li, R Sun, J Ji, F Yang, W Tian, W Ji… - Frontiers in …, 2022 - frontiersin.org
Background Cuproptosis, a genetic process of copper-dependent cell death linked to
mitochondria respiration, demonstrates its correlation with inhibiting tumoral angiogenesis …

Inflammation and regulatory T cell genes are differentially expressed in peripheral blood mononuclear cells of Parkinson's disease patients

Z Karaaslan, ÖT Kahraman, E Şanlı, HA Ergen… - Scientific reports, 2021 - nature.com
Our aim was to identify the differentially expressed genes (DEGs) in peripheral blood
mononuclear cells (PBMC) of Parkinson's disease (PD) patients and healthy controls by …

Integrated analysis and identification of novel biomarkers in Parkinson's disease

J Chi, Q Xie, J Jia, X Liu, J Sun, Y Deng… - Frontiers in Aging …, 2018 - frontiersin.org
Parkinson's disease (PD) is a quite common neurodegenerative disorder with a prevalence
of approximately 1: 800–1,000 in subjects over 60 years old. The aim of our study was to …

Large-scale pathway specific polygenic risk and transcriptomic community network analysis identifies novel functional pathways in Parkinson disease

S Bandres-Ciga, S Saez-Atienzar, JJ Kim… - Acta …, 2020 - Springer
Polygenic inheritance plays a central role in Parkinson disease (PD). A priority in elucidating
PD etiology lies in defining the biological basis of genetic risk. Unraveling how risk leads to …

Inflammation biomarker discovery in Parkinson's disease and atypical parkinsonisms

A Santaella, HB Kuiperij, A van Rumund, RAJ Esselink… - BMC neurology, 2020 - Springer
Background Parkinson's disease (PD) and atypical parkinsonisms (APD) have overlapping
symptoms challenging an early diagnosis. Diagnostic accuracy is important because PD …

Exploring the Communal Pathogenesis, Ferroptosis Mechanism, and Potential Therapeutic Targets of Dilated Cardiomyopathy and Hypertrophic Cardiomyopathy via …

Z Wang, Q Xia, W Su, M Cao, Y Sun… - Frontiers in …, 2022 - frontiersin.org
Background Cardiomyopathies are a heterogeneous group of heart diseases that can
gradually cause severe heart failure. In particular, dilated cardiomyopathy (DCM) and …