Highlights•Chromatin regulators orchestrate the pace and order of gene expression
programs in differentiating neurons.•Disease-associated mutations in chromatin regulators …

Neurons are dynamic cells that respond and adapt to stimuli throughout their long
postmitotic lives. The structural and functional plasticity of neurons requires the regulated …

Epigenetic mechanisms convey information above and beyond the sequence of DNA, so it is
predicted that they are critical in the complex regulation of brain development and explain …

Chromatin-related genes are frequently mutated in neurodevelopmental disorders; yet, the
mechanisms by which these perturbations disrupt brain assembly and function are not …

Background: The transcriptional control of neuronal specification and early development has
been intensively studied over the past few decades. However, relatively little is known about …

Neurons are submitted to an exceptional variety of stimuli and are able to convert these into
high-order functions, such as storing memories, controlling behavior, and governing …

Chromatin structure is an essential regulator of gene expression. Its state of compaction
contributes to the regulation of genetic programs, in particular during differentiation …

Epigenetic regulation of gene expression is critical during development of the central
nervous system. Pathogenic variants in genes encoding epigenetic factors have been found …

Epigenetic regulation plays an important role in controlling gene expression during complex
processes, such as development of the human brain. Mutations in genes encoding …

Neural stem cells generate distinct cell types for tissue formation and cell replacement
during development and throughout adulthood. Neural development and plasticity are …