COVID‐19 is an emergent disease of aging

D Santesmasses, JP Castro, AA Zenin… - Aging cell, 2020 - Wiley Online Library
COVID‐19 is an ongoing pandemic caused by the SARS‐CoV‐2 coronavirus that poses one
of the greatest challenges to public health in recent years. SARS‐CoV‐2 is known to …

Cellular senescence as a potential mediator of COVID‐19 severity in the elderly

J Nehme, M Borghesan, S Mackedenski, TG Bird… - Aging cell, 2020 - Wiley Online Library
SARS‐CoV‐2 is a novel betacoronavirus which infects the lower respiratory tract and can
cause coronavirus disease 2019 (COVID‐19), a complex respiratory distress syndrome …

[HTML][HTML] Why does COVID-19 disproportionately affect older people?

AL Mueller, MS McNamara, DA Sinclair - Aging (albany NY), 2020 - ncbi.nlm.nih.gov
The severity and outcome of coronavirus disease 2019 (COVID-19) largely depends on a
patient's age. Adults over 65 years of age represent 80% of hospitalizations and have a 23 …

COVID-19 in older adults

A Nanda, NVRK Vura, S Gravenstein - Aging clinical and experimental …, 2020 - Springer
The advent of the SARS-CoV-2 and COVID-19 pandemic has generated a lot of publications
at a rapid pace. We know that older adults disproportionately suffer the most severe of …

Susceptibility of the elderly to SARS-CoV-2 infection: ACE-2 overexpression, shedding, and antibody-dependent enhancement (ADE)

JPS Peron, H Nakaya - Clinics, 2020 - SciELO Brasil
The world is currently facing a serious SARS-CoV-2 infection pandemic. This virus is a new
isolate of coronavirus, and the current infection crisis has surpassed the SARS and MERS …

COVID-19 and crosstalk with the hallmarks of aging

S Salimi, JM Hamlyn - The Journals of Gerontology: Series A, 2020 - academic.oup.com
Within the past several decades, the emergence of new viral diseases with severe health
complications and mortality is evidence of an age-dependent, compromised bodily response …

Exploring the relevance of senotherapeutics for the current SARS-CoV-2 emergency and similar future global health threats

M Malavolta, R Giacconi, D Brunetti, M Provinciali… - Cells, 2020 - mdpi.com
The higher death rate caused by COVID-19 in older people, especially those with
comorbidities, is a challenge for biomedical aging research. Here we explore the idea that …

Aging in COVID-19: Vulnerability, immunity and intervention

Y Chen, SL Klein, BT Garibaldi, H Li, C Wu… - Ageing research …, 2021 - Elsevier
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic was first
reported in Wuhan, China in December 2019, moved across the globe at an unprecedented …

The aging transcriptome and cellular landscape of the human lung in relation to SARS-CoV-2

RD Chow, M Majety, S Chen - Nature Communications, 2021 - nature.com
Age is a major risk factor for severe coronavirus disease-2019 (COVID-19). Here, we
interrogate the transcriptional features and cellular landscape of the aging human lung. By …

Geriatric population during the COVID-19 pandemic: problems, considerations, exigencies, and beyond

K Dhama, SK Patel, R Kumar, J Rana… - Frontiers in public …, 2020 - frontiersin.org
The coronavirus disease 2019 (COVID-19) pandemic wreaked havoc worldwide, with more
than 20 million confirmed cases and nearly 0. 75 million deaths as of 10th August 2020 …