Biomarkers of ageing and frailty may predict COVID-19 severity

KJ Wanhella, C Fernandez-Patron - Ageing research reviews, 2022 - Elsevier
Abstract Coronavirus Disease 2019 (COVID-19) is caused by the novel coronavirus, Severe
Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2)-the culprit of an ongoing …

[HTML][HTML] Age-related morbidity and mortality among patients with COVID-19

SJ Kang, SI Jung - Infection & chemotherapy, 2020 - ncbi.nlm.nih.gov
Abstract On March 11, 2020, the World Health Organization declared coronavirus disease
(COVID-19), caused by the novel coronavirus severe acute respiratory syndrome …

Severe COVID-19 and aging: are monocytes the key?

BD Pence - Geroscience, 2020 - Springer
The ongoing pandemic severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)
causes a disproportionate number of severe cases and deaths in older adults. Severe SARS …

A geroscience perspective on COVID-19 mortality

DEL Promislow - The journals of gerontology: Series A, 2020 - academic.oup.com
A novel coronavirus, SARS-CoV-2, emerged in December 2019, leading within a few
months to a global pandemic. COVID-19, the disease caused by this highly contagious virus …

[HTML][HTML] From causes of aging to death from COVID-19

MV Blagosklonny - Aging (Albany NY), 2020 - ncbi.nlm.nih.gov
COVID-19 is not deadly early in life, but mortality increases exponentially with age, which is
the strongest predictor of mortality. Mortality is higher in men than in women, because men …

Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 severity

Z Inde, BA Croker, C Yapp, GN Joshi, J Spetz… - Science …, 2021 - science.org
Novel coronavirus disease 2019 (COVID-19) severity is highly variable, with pediatric
patients typically experiencing less severe infection than adults and especially the elderly …

SARS-CoV-2 infection triggers paracrine senescence and leads to a sustained senescence-associated inflammatory response

S Tsuji, S Minami, R Hashimoto, Y Konishi, T Suzuki… - Nature aging, 2022 - nature.com
Reports of post-acute COVID-19 syndrome, in which the inflammatory response persists
even after SARS-CoV-2 has disappeared, are increasing, but the underlying mechanisms of …

Inflamm-aging: Why older men are the most susceptible to SARS-CoV-2 complicated outcomes

M Bonafè, F Prattichizzo, A Giuliani, G Storci… - Cytokine & Growth …, 2020 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is characterized
by a high mortality of elderly men with age-related comorbidities. In most of these patients …

Aging, immunity, and COVID-19: how age influences the host immune response to coronavirus infections?

V Bajaj, N Gadi, AP Spihlman, SC Wu, CH Choi… - Frontiers in …, 2021 - frontiersin.org
The novel coronavirus severe acute respiratory syndrome coronavirus 2 causing the
Coronavirus disease (COVID-19) pandemic has ravaged the world with over 72 million total …

SARS-CoV-2, COVID-19 and the aging immune system

JM Bartleson, D Radenkovic, AJ Covarrubias… - Nature aging, 2021 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic is a global health threat with
particular risk for severe disease and death in older adults and in adults with age-related …