[HTML][HTML] A diminished immune response underlies age-related SARS-CoV-2 pathologies
Morbidity and mortality in response to SARS-CoV-2 infection are significantly elevated in
people of advanced age. To understand the underlying biology of this phenotype, we utilize …
people of advanced age. To understand the underlying biology of this phenotype, we utilize …
Immunosenescence and inflamm-ageing in COVID-19
The destructive effects of coronavirus disease 2019 (COVID-19) on the elderly and people
with cardiovascular disease have been proven. New findings shed light on the role of aging …
with cardiovascular disease have been proven. New findings shed light on the role of aging …
The dilemma of coronavirus disease 2019, aging, and cardiovascular disease: insights from cardiovascular aging science
M AlGhatrif, O Cingolani, EG Lakatta - JAMA cardiology, 2020 - jamanetwork.com
As we brace for the imminent impact of the coronavirus disease 2019 (COVID-19) pandemic,
we are faced with a controversy on how to best minimize the risk of lethal disease among the …
we are faced with a controversy on how to best minimize the risk of lethal disease among the …
Individual variation of the SARS‐CoV‐2 receptor ACE2 gene expression and regulation
The COVID‐19 coronavirus is now spreading worldwide. Its pathogen, SARS‐CoV‐2, has
been shown to use angiotensin‐converting enzyme 2 (ACE2) as its host cell receptor, same …
been shown to use angiotensin‐converting enzyme 2 (ACE2) as its host cell receptor, same …
COVID-19 and the elderly: who cares?
F Fischer, L Raiber, C Boscher… - Frontiers in public health, 2020 - frontiersin.org
Reports and discussions about the current situation and state of knowledge, information
about risks and protective behaviors, and predictions of future scenarios related to COVID …
about risks and protective behaviors, and predictions of future scenarios related to COVID …
Role of aging and the immune response to respiratory viral infections: potential implications for COVID-19
J Chen, WJ Kelley, DR Goldstein - The Journal of Immunology, 2020 - journals.aai.org
Aging impairs immunity to promote diseases, especially respiratory viral infections. The
current COVID-19 pandemic, resulting from SARS-CoV-2, induces acute pneumonia, a …
current COVID-19 pandemic, resulting from SARS-CoV-2, induces acute pneumonia, a …
Accelerated biological aging in COVID-19 patients
Chronological age is a risk factor for SARS-CoV-2 infection and severe COVID-19. Previous
findings indicate that epigenetic age could be altered in viral infection. However, the …
findings indicate that epigenetic age could be altered in viral infection. However, the …
Pulmonary infection by SARS-CoV-2 induces senescence accompanied by an inflammatory phenotype in severe COVID-19: possible implications for viral …
K Evangelou, D Veroutis, K Paschalaki… - European …, 2022 - Eur Respiratory Soc
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection of
the respiratory system can progress to a multisystemic disease with aberrant inflammatory …
the respiratory system can progress to a multisystemic disease with aberrant inflammatory …
Racial and gender-based differences in COVID-19
The novel coronavirus disease (COVID-19) has become a global health crisis since its first
appearance in Wuhan, China. Current epidemiological studies suggest that COVID-19 …
appearance in Wuhan, China. Current epidemiological studies suggest that COVID-19 …
COVID-19 mortality as a fingerprint of biological age
Abstract Corona virus disease 2019 (COVID-19) is a global emergency able to overwhelm
the healthcare capacities worldwide and to affect the older generation especially. When …
the healthcare capacities worldwide and to affect the older generation especially. When …