[HTML][HTML] COVID-19 severity is predicted by earlier evidence of accelerated aging

CL Kuo, LC Pilling, JL Atkins, JAH Masoli, J Delgado… - Medrxiv, 2020 - ncbi.nlm.nih.gov
With no known treatments or vaccine, COVID-19 presents a major threat, particularly to older
adults, who account for the majority of severe illness and deaths. The age-related …

[HTML][HTML] How does SARS-CoV-2 targets the elderly patients? A review on potential mechanisms increasing disease severity

A Smorenberg, EJG Peters, PLA van Daele… - European Journal of …, 2021 - Elsevier
Abstract Importance: Among COVID-19 cases, especially the (frail) elderly show a high
number of severe infections, hospital admissions, complications, and death. The highest …

Cellular and molecular biomarkers of long COVID: a scoping review

E Espín, C Yang, CP Shannon, S Assadian, D He… - …, 2023 - thelancet.com
Summary Background Long-COVID (LC) encompasses diverse symptoms lasting months
after the initial SARS-CoV-2 infection. Symptoms can be debilitating and affect the quality of …

Virus-induced senescence is a driver and therapeutic target in COVID-19

S Lee, Y Yu, J Trimpert, F Benthani, M Mairhofer… - Nature, 2021 - nature.com
Derailed cytokine and immune cell networks account for the organ damage and the clinical
severity of COVID-19 (refs.,,–). Here we show that SARS-CoV-2, like other viruses, evokes …

COVID-19 and quarantine, a catalyst for ageism

N Barth, J Guyot, SA Fraser, M Lagacé… - Frontiers in public …, 2021 - frontiersin.org
In February 2021, France had more than 76,000 deaths due to COVID-19 and older adults
were heavily affected. Most measures taken to reduce the impact of COVID-19 (quarantine …

The COVID-19 pandemic: does our early life environment, life trajectory and socioeconomic status determine disease susceptibility and severity?

C Holuka, MP Merz, SB Fernandes… - International journal of …, 2020 - mdpi.com
A poor socioeconomic environment and social adversity are fundamental determinants of
human life span, well-being and health. Previous influenza pandemics showed that …

COVID-19: characteristics and therapeutics

R Chilamakuri, S Agarwal - Cells, 2021 - mdpi.com
Novel coronavirus (COVID-19 or 2019-nCoV or SARS-CoV-2), which suddenly emerged in
December 2019 is still haunting the entire human race and has affected not only the …

Pathogenesis of COVID-19-induced ARDS: implications for an ageing population

MAT Acosta, BD Singer - European Respiratory Journal, 2020 - Eur Respiratory Soc
The coronavirus disease 2019 (COVID-19) pandemic has elicited a swift response by the
scientific community to elucidate the pathogenesis of severe acute respiratory syndrome …

[HTML][HTML] COVID-19, virology and geroscience: a perspective

C Vellas, P Delobel, PDS Barreto, J Izopet - The journal of nutrition, health …, 2020 - Elsevier
A new coronavirus, called SARS-CoV-2, was identified in Wuhan, China, in December 2019.
The SARS-CoV-2 spread very rapidly, causing a global pandemic, Coronavirus Disease …

COVID-19 and the elderly: insights into pathogenesis and clinical decision-making

F Perrotta, G Corbi, G Mazzeo, M Boccia… - Aging clinical and …, 2020 - Springer
The elderly may represent a specific cluster of high-risk patients for developing COVID-19
with rapidly progressive clinical deterioration. Indeed, in older individuals …