Perturbation of metabolism elicits cellular stress which profoundly modulates the cellular
proteome and thus protein homeostasis (proteostasis). Consequently, changes in the …

Abstract The NIH Summit, Advances in Geroscience: Impact on Health Span and Chronic
Disease, discusses several aspects of cellular degeneration that underlie susceptibility to …

Metabolic changes are hallmarks of aging and genetic and pharmacologic alterations of
relevant pathways can extend life span. In this review, we will outline how cellular …

Aging cells accumulate damaged and misfolded proteins through a functional decline in
their protein homeostasis (proteostasis) machinery, leading to reduced cellular viability and …

Aging and longevity are controlled by a multiplicity of molecular and cellular signaling
events that interface with environmental factors to maintain cellular homeostasis. Modulation …

The health of an organism is orchestrated by a multitude of molecular and biochemical
networks responsible for ensuring homeostasis within cells and tissues. However, upon …

Molecular and cellular networks implicated in aging depend on a multitude of proteins that
collectively mount adaptive and contingent metabolic responses to environmental …

Cellular homeostasis, which is needed for the cells to survive, requires a well-controlled
balance in protein turnover. Both protein synthesis and degradation are influenced by …

Aging is a complex process regulated by multiple cellular pathways, including the
proteostasis network. The proteostasis network consists of molecular chaperones, stress …

Accumulation of intracellular damage is an almost universal hallmark of aging. An improved
understanding of the systems that contribute to cellular protein quality control has shed light …