Frailty encompasses several domains (ie, metabolic, physical, cognitive). The multisystem
derangements underlying frailty pathophysiology, its phenotypic heterogeneity, and the …

All cells count on precise mechanisms that regulate protein homeostasis to maintain a stable
and functional proteome. Alterations in these fine-tuned mechanisms underlie the …

Aging is a fundamental biological process accompanied by a general decline in tissue
function. Indeed, as the lifespan increases, age-related dysfunction, such as cognitive …

Loss of proteostasis and cellular senescence are key hallmarks of aging, but direct cause-
effect relationships are not well understood. We show that most yeast cells arrest in G1 …

Aging is characterized by a progressive loss of physiological integrity, leading to impaired
function and increased vulnerability to death. This deterioration is the primary risk factor for …

It has been well established that most of the age-related diseases such as insulin resistance,
type 2 diabetes, hypertension, cardiovascular disease, osteoporosis, and atherosclerosis …

Both life span and health span are influenced by genetic, environmental and lifestyle factors.
With the genetic influence on human life span estimated to be about 20–25%, epigenetic …

Cellular senescence, a stable cell division arrest caused by severe damage and stress, is a
hallmark of aging in vertebrates including humans. With progressing age, senescent cells …

All cells count on precise mechanisms that regulate protein homeostasis to maintain a stable
and functional proteome. A progressive deterioration in the ability of cells to preserve the …

Energy metabolism, including alterations in energy intake and expenditure, is closely related
to aging and longevity. Metabolomics studies have recently unraveled changes in …