Age-associated changes in immune cells have been linked to an increased risk for infection.
However, a global and detailed characterization of the changes that human circulating …

The ongoing pandemic severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)
causes a disproportionate number of severe cases and deaths in older adults. Severe SARS …

COVID-19 disease outcome is highly dependent on adaptive immunity from T and B
lymphocytes, which play a critical role in the control, clearance and long-term protection …

Aging is a major risk factor for developing severe COVID-19, but few detailed data are
available concerning immunological changes after infection in aged individuals. Here we …

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), has resulted in a global pandemic associated with substantial …

Morbidity and mortality in response to SARS-CoV-2 infection are significantly elevated in
people of advanced age. To understand the underlying biology of this phenotype, we utilize …

Elderly individuals are the most susceptible to an aggressive form of coronavirus disease
(COVID-19), caused by SARS-CoV-2. The remodeling of immune response that is observed …

Bearing a strong resemblance to the phenotypic and functional remodeling of the immune
system that occurs during aging (termed immunesenescence), the immune response to …

Abstract Coronavirus disease 2019 (COVID-19) is a respiratory infectious disease caused
by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 is …

Covid-19 and Immunity in Aging Populations As billions of dollars flow into research and
development efforts aimed at controlling SARS-CoV-2, the pandemic response remains …