[HTML][HTML] Age-related DNA methylation changes are sex-specific: a comprehensive assessment
I Yusipov, MG Bacalini, A Kalyakulina… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
The existence of a sex gap in human health and longevity has been widely documented.
Autosomal DNA methylation differences between males and females have been reported …
Autosomal DNA methylation differences between males and females have been reported …
DNA methylation and healthy human aging
The process of aging results in a host of changes at the cellular and molecular levels, which
include senescence, telomere shortening, and changes in gene expression. Epigenetic …
include senescence, telomere shortening, and changes in gene expression. Epigenetic …
Role of epigenetics in human aging and longevity: genome-wide DNA methylation profile in centenarians and centenarians' offspring
The role of epigenetics in the modulation of longevity has not been studied in humans. To
this aim,(1) we evaluated the DNA methylation from peripheral leukocytes of 21 female …
this aim,(1) we evaluated the DNA methylation from peripheral leukocytes of 21 female …
Epigenetic genome-wide association methylation in aging and longevity
D Ben-Avraham, RH Muzumdar, G Atzmon - Epigenomics, 2012 - Taylor & Francis
The aging phenotype is the result of a complex interaction between genetic, epigenetic and
environmental factors. Evidence suggests that epigenetic changes (ie, a set of reversible …
environmental factors. Evidence suggests that epigenetic changes (ie, a set of reversible …
Obesity accelerates epigenetic aging in middle-aged but not in elderly individuals
T Nevalainen, L Kananen, S Marttila, J Jylhävä… - Clinical …, 2017 - Springer
Background Human aging is associated with profound changes in one of the major
epigenetic mechanisms, DNA methylation. Some of these changes occur in a clock-like …
epigenetic mechanisms, DNA methylation. Some of these changes occur in a clock-like …
An epigenome-wide association study of sex-specific chronological ageing
Background Advanced age is associated with cognitive and physical decline and is a major
risk factor for a multitude of disorders. There is also a gap in life expectancy between males …
risk factor for a multitude of disorders. There is also a gap in life expectancy between males …
[HTML][HTML] Cell and tissue type independent age-associated DNA methylation changes are not rare but common
Age-associated DNA methylation changes have been widely reported across many different
tissue and cell types. Epigenetic 'clocks' that can predict chronological age with a …
tissue and cell types. Epigenetic 'clocks' that can predict chronological age with a …
Global DNA methylation in old subjects is correlated with frailty
Epigenetic variations have been widely described to occur during the aging process. To
verify if these modifications are correlated with the inter-individual phenotypic variability of …
verify if these modifications are correlated with the inter-individual phenotypic variability of …
Making sense of the ageing methylome
Over time, the human DNA methylation landscape accrues substantial damage, which has
been associated with a broad range of age-related diseases, including cardiovascular …
been associated with a broad range of age-related diseases, including cardiovascular …
Continuous aging of the human DNA methylome throughout the human lifespan
Å Johansson, S Enroth, U Gyllensten - PloS one, 2013 - journals.plos.org
DNA methylation plays an important role in development of disease and the process of
aging. In this study we examine DNA methylation at 476,366 sites throughout the genome of …
aging. In this study we examine DNA methylation at 476,366 sites throughout the genome of …