The incidence of cancer, adjusted for secular trends, is directly related to age, and advanced
chronologic age is one of the most significant risk factors for cancer. Organismal aging is …

DNA methylation acts in concert with other epigenetic mechanisms to regulate normal gene
expression and facilitate chromatin organization within cells. Aberrant DNA methylation …

Overall shared DNA methylation patterns between senescence (Sen) and cancers have led
to the model that tumor-promoting epigenetic patterns arise through senescence. We show …

Patterns of DNA methylation and chromatin structure are profoundly altered in neoplasia
and include genome-wide losses of, and regional gains in, DNA methylation. The recent …

Preserving genome function and stability are paramount for ensuring cellular homeostasis,
an imbalance in which can promote diseases including cancer. In the presence of DNA …

Appropriate patterns of DNA methylation and histone modifications are required to assure
cell identity, and their deregulation can contribute to human diseases, such as cancer. Our …

Altered DNA methylation and associated destabilization of genome integrity and function is
a hallmark of cancer. Replicative senescence is a tumour suppressor process that imposes …

Aging is characterized by functional decline of diverse organs and an increased risk for
several diseases. Therefore, a high interest exists in understanding the molecular …

Epigenetics has long been recognized as a significant field in biology and is defined as the
investigation of any alteration in gene expression patterns that is not attributed to changes in …

We are at the dawn of an era when epigenetic drugs will be an important weapon in our
arsenal in the war against cancer. Hematological malignancies have provided a promising …