Background Human lifespan is approximately 25% heritable, and genetic factors may be
particularly important for achieving exceptional longevity. Accordingly, siblings of …

Background Although there is abundant evidence that human longevity is heritable, efforts to
map loci responsible for variation in human lifespan have had limited success …

Loci associated with longevity are likely to harbor genes coding for key players of molecular
pathways involved in a lifelong decreased mortality and decreased/compressed morbidity …

Like most complex phenotypes, exceptional longevity is thought to reflect a combined
influence of environmental (eg, lifestyle choices, where we live) and genetic factors. To …

Background Longevity as a phenotype entails living longer than average and typically
includes living without chronic age-related diseases. Recently, several common genetic …

The search for the genetic determinants of extreme human longevity has been challenged
by the phenotype's rarity and its nonspecific definition by investigators. To address these …

We developed a new statistical framework to find genetic variants associated with extreme
longevity. The method, informed GWAS (iGWAS), takes advantage of knowledge from large …

Clear evidence exists for heritability of human longevity, and much interest is focused on
identifying genes associated with longer lives. To identify such longevity alleles, we …

We performed a genome-wide association study (GWAS) of human extreme longevity (EL),
defined as surviving past the 99th survival percentile, by aggregating data from four …

Substantial evidence supports the familial aggregation of exceptional longevity. The
existence of rare families demonstrating clustering for this phenotype suggests that a genetic …