Homology between the DNA-binding domain of the GCN4 regulatory protein of yeast and the carboxyl-terminal region of a protein coded for by the oncogene jun.
PK Vogt, TJ Bos, RF Doolittle - Proceedings of the National …, 1987 - National Acad Sciences
The product of the recently described oncogene jun shows significant amino acid sequence
homology with the GCN4 yeast transcriptional activator protein. The similarity is restricted to …
homology with the GCN4 yeast transcriptional activator protein. The similarity is restricted to …
The DNA-binding domains of the jun oncoprotein and the yeast GCN4 transcriptional activator protein are functionally homologous
K Struhl - Cell, 1987 - cell.com
The jun oncoprotein, which causes sarcomas in chickens, and the DNA-binding domain of
yeast GCN4, which coordinately regulates the expression of amino acid biosynthetic genes …
yeast GCN4, which coordinately regulates the expression of amino acid biosynthetic genes …
Yeast YAP1 encodes a novel form of the jun family of transcriptional activator proteins.
WS Moye-Rowley, KD Harshman… - Genes & …, 1989 - genesdev.cshlp.org
The jun family of transcriptional activators includes mammalian AP-1 as well as the yeast
regulatory protein GCN4. Recently, an additional transcriptional activator has been found in …
regulatory protein GCN4. Recently, an additional transcriptional activator has been found in …
The oncogene jun and nuclear signalling
PK Vogt, TJ Bos - Trends in biochemical sciences, 1989 - cell.com
Jun is a transcription factor that can also induce oncogenic transformation. Its tional
equivalence. A chimeric GCN4 DNA-binding domain is conserved from yeast to man and …
equivalence. A chimeric GCN4 DNA-binding domain is conserved from yeast to man and …
The JUN oncoprotein, a vertebrate transcription factor, activates transcription in yeast
K Struhl - Nature, 1988 - nature.com
Transcriptional activation of RNA polymerase II in eukaryotic organisms ranging from yeasts
to mammals has many common features such as enhancer elements, TATA elements, and …
to mammals has many common features such as enhancer elements, TATA elements, and …
Changing Fos oncoprotein to a Jun-independent DNA-binding protein with GCN4 dimerization specificity by swapping" leucine zippers"
JW Sellers, K Struhl - Nature, 1989 - nature.com
Abstract A STRUCTURAL motif for DNA-binding proteins, the" leucine zipper", has been
proposed for the jun, fos and myc gene products, the yeast transcriptional activator GCN4 …
proposed for the jun, fos and myc gene products, the yeast transcriptional activator GCN4 …
A gene activated by growth factors is related to the oncogene v-jun.
K Ryder, LF Lau, D Nathans - Proceedings of the National …, 1988 - National Acad Sciences
We have recently identified by cDNA cloning a set of genes that are rapidly activated in
cultured mouse cells by protein growth factors. Here we report that the nucleotide sequence …
cultured mouse cells by protein growth factors. Here we report that the nucleotide sequence …
Oncogene jun encodes a sequence-specific trans- activator similar to AP-1
P Angel, EA Allegretto, ST Okino, K Hattori, WJ Boyle… - Nature, 1988 - nature.com
Proto-oncogenes encode proteins with three main sites of action: the cell-surface
membrane, the cytoplasm and the nucleus1, 2. Although the exact biochemical function of …
membrane, the cytoplasm and the nucleus1, 2. Although the exact biochemical function of …
[引用][C] Fos and Jun: the AP-1 connection
T Curran, BR Franza Jr - Cell, 1988 - Elsevier
Oncogene research has led to the isolation of specific reagents that have allowed important
insights in several disciplines. Recently, studies on oncogenes encoding nuclear proteins …
insights in several disciplines. Recently, studies on oncogenes encoding nuclear proteins …
jun-D: a third member of the jun gene family.
K Ryder, A Lanahan… - Proceedings of the …, 1989 - National Acad Sciences
The protooncogene c-jun encodes a component of the transcription factor AP-1. Both murine
c-jun and a related gene (jun-B) are rapidly activated in BALB/c3T3 cells by serum growth …
c-jun and a related gene (jun-B) are rapidly activated in BALB/c3T3 cells by serum growth …