Epigenetic age acceleration reflects long-term cardiovascular health
Rationale: Epigenetic aging is a novel measure of biological age, reflecting exposures and
disease risks independent of chronological age. It may serve as a useful biomarker of …
disease risks independent of chronological age. It may serve as a useful biomarker of …
Prospective study of epigenetic age acceleration and incidence of cardiovascular disease outcomes in the ARIC study (Atherosclerosis Risk in Communities)
NS Roetker, JS Pankow, J Bressler… - Circulation: Genomic …, 2018 - Am Heart Assoc
Background: DNA methylation-based patterns of biological aging, known as epigenetic age
acceleration, are predictive of all-cause mortality, but little is known about their association …
acceleration, are predictive of all-cause mortality, but little is known about their association …
Genetic evidence for causal effects of socioeconomic, lifestyle, and cardiometabolic factors on epigenetic-age acceleration
Abstract GrimAge acceleration (GrimAgeAccel) and PhenoAge acceleration
(PhenoAgeAccel) are DNA methylation-based markers of accelerated biological aging …
(PhenoAgeAccel) are DNA methylation-based markers of accelerated biological aging …
Epigenetic modifications in cardiovascular aging and diseases
Aging is associated with a progressive decline in cardiovascular structure and function.
Accumulating evidence links cardiovascular aging to epigenetic alterations encompassing a …
Accumulating evidence links cardiovascular aging to epigenetic alterations encompassing a …
Association of cardiovascular health and epigenetic age acceleration
Background Cardiovascular health (CVH) has been defined by the American Heart
Association (AHA) as the presence of the “Life's Simple 7” ideal lifestyle and clinical factors …
Association (AHA) as the presence of the “Life's Simple 7” ideal lifestyle and clinical factors …
The intersection between aging and cardiovascular disease
BJ North, DA Sinclair - Circulation research, 2012 - Am Heart Assoc
The average lifespan of humans is increasing, and with it the percentage of people entering
the 65 and older age group is growing rapidly and will continue to do so in the next 20 years …
the 65 and older age group is growing rapidly and will continue to do so in the next 20 years …
Cardiovascular health and four epigenetic clocks
YH Lo, WY Lin - Clinical Epigenetics, 2022 - Springer
Background Cardiovascular health (CVH) was defined by the American Heart Association
as an integrative idealness of seven clinical or lifestyle factors. Based on populations of …
as an integrative idealness of seven clinical or lifestyle factors. Based on populations of …
Epigenetic age acceleration and metabolic syndrome in the coronary artery risk development in young adults study
Abstract Background The metabolic syndrome (MetS) is a collection of metabolic
disturbances that can lead to various cardiovascular diseases. Previous studies have shown …
disturbances that can lead to various cardiovascular diseases. Previous studies have shown …
Education and lifestyle factors are associated with DNA methylation clocks in older African Americans
DNA methylation (DNAm) clocks are important biomarkers of cellular aging and are
associated with a variety of age-related chronic diseases and all-cause mortality. Examining …
associated with a variety of age-related chronic diseases and all-cause mortality. Examining …
An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease
Background Epigenetic biomarkers of aging (the “epigenetic clock”) have the potential to
address puzzling findings surrounding mortality rates and incidence of cardio-metabolic …
address puzzling findings surrounding mortality rates and incidence of cardio-metabolic …