There is overwhelming evidence that DNA methylation patterns are altered in cancer.
Methylation of CG-rich islands in regulatory regions of genes marks them for transcriptional …

Methylation of DNA is known to be an important mechanism of gene regulation. A hallmark
of cancer is the deregulation of the DNA methylation machinery and aberrant DNA …

DNA methylation is one of the most extensively studied, and one of the most stable, of all
epigenetic modifications. Two drugs that target DNA methyltransferase enzymes are …

DNA methylation, a reversible post-replication modification, defines gene expression and
function in different physiologic processes. Hypomethylation is quite common among global …

The field of epigenetics has recently moved to the forefront of studies relating to diverse
processes such as transcriptional regulation, chromatin structure, genome integrity, and …

DNA methyltransferase is an enzyme responsible for generating and maintaining DNA
methylation patterns. DNA methylation patterns control different genome functions, thus they …

The epigenome, which is comprised of chromatin and its associated proteins and the
patterns of covalent modification of DNA by methylation, sets up and maintains gene …

Cancer growth and metastasis requires reprogramming of the expression of multiple genes.
The epigenome, which is comprised of chromatin and the patterns of DNA methylation, sets …

DNA methylation is now recognized as an important mechanism regulating different
functions of the genome; gene expression, replication, and cancer. Different factors control …

Epigenetic mechanisms are essential for normal development and maintenance of tissue-
specific gene expression patterns in mammals. Disruption of epigenetic processes can lead …