[HTML][HTML] A survey of genetic variants in SARS-CoV-2 interacting domains of ACE2, TMPRSS2 and TLR3/7/8 across populations

IH Lee, JW Lee, SW Kong - Infection, Genetics and Evolution, 2020 - Elsevier
The COVID-19 pandemic highlighted healthcare disparities in multiple countries. As such
morbidity and mortality vary significantly around the globe between populations and ethnic …

Lack of Association Between Genetic Variants at ACE2 and TMPRSS2 Genes Involved in SARS-CoV-2 Infection and Human Quantitative Phenotypes

EA Lopera Maya, A Van der Graaf, P Lanting… - Frontiers in …, 2020 - frontiersin.org
Coronavirus disease 2019 (COVID-19) shows a wide variation in expression and severity of
symptoms, from very mild or no symptoms, to flu-like symptoms, and in more severe cases …

[HTML][HTML] The relationship between the clinical course of SARS-CoV-2 infections and ACE2 and TMPRSS2 expression and polymorphisms

E Tug, I Fidan, G Bozdayi, F Yildirim… - … in Clinical and …, 2024 - advances.umw.edu.pl
Background. The viral spike (S) protein and host ACE2 and TMPRSS2 genetic variations
may act as a barrier to viral infections or determine susceptibility to severe acute respiratory …

Contributions of human ACE2 and TMPRSS2 in determining host–pathogen interaction of COVID-19

S Senapati, P Banerjee, S Bhagavatula… - Journal of genetics, 2021 - Springer
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is at present an
emerging global public health crisis. Angiotensin converting enzyme 2 (ACE2) and trans …

SARS-CoV-2 entry related viral and host genetic variations: implications on COVID-19 severity, immune escape, and infectivity

SW Huang, SF Wang - International Journal of Molecular Sciences, 2021 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved to display
particular patterns of genetic diversity in the genome across geographical regions. These …

Infectivity and progression of COVID-19 based on selected host candidate gene variants

GR Iyer, S Samajder, S Zubeda, V Mali, SK Pv… - Frontiers in …, 2020 - frontiersin.org
Introduction: Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has spread
around the globe. Susceptibility has been associated with age, biological sex, and other …

Polymorphisms within the SARS-CoV-2 human receptor genes associate with variable disease outcomes across ethnicities

T Adimulam, T Arumugam, A Naidoo, K Naidoo… - Genes, 2023 - mdpi.com
The contribution of human genes to the variability of disease outcomes has been shown to
be important across infectious diseases. Studies have shown mutations within specific …

SARS-CoV-2 Susceptibility and ACE2 Gene Variations Within Diverse Ethnic Backgrounds

N Vadgama, A Kreymerman, J Campbell… - Frontiers in …, 2022 - frontiersin.org
There is considerable variability in the susceptibility and progression for COVID-19 and it
appears to be strongly correlated with age, gender, ethnicity and pre-existing health …

Genetic variants that influence SARS-CoV-2 receptor TMPRSS2 expression among population cohorts from multiple continents

LM Irham, WH Chou, MJ Calkins, W Adikusuma… - Biochemical and …, 2020 - Elsevier
Abstract The World Health Organization recently announced that pandemic status has been
achieved for coronavirus disease 2019 (COVID-19), which is caused by severe acute …

Analysis of ACE2 and TMPRSS2 coding variants as a risk factor for SARS‐CoV‐2 from 946 whole‐exome sequencing data in the Turkish population

N Duman, G Tuncel, A Bisgin… - Journal of medical …, 2022 - Wiley Online Library
Heterogeneity in symptoms associated with COVID‐19 in infected patients remains unclear.
ACE2 and TMPRSS2 gene variants are considered possible risk factors for COVID‐19. In …